Devices, methods, and kits for non-invasive glucose measurement
First Claim
1. A skin patch for use with a glucose measurement device comprising:
- an adhesive material;
a collection layer for collecting sweat;
a sweat-permeable membrane, whereby the sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion;
a detector configured to detect nanogram quantities of glucose; and
an interface layer.
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Accused Products
Abstract
Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
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Citations
48 Claims
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1. A skin patch for use with a glucose measurement device comprising:
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an adhesive material;
a collection layer for collecting sweat;
a sweat-permeable membrane, whereby the sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion;
a detector configured to detect nanogram quantities of glucose; and
an interface layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 38, 40, 41, 42, 43)
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25. A glucose measurement device for use with a skin patch comprising:
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a display;
a processor;
computer executable code for executing a calibration algorithm; and
an ultra-sensitive measurement mechanism for measuring glucose collected in a corresponding patch, whereby the measurement mechanism is configured to measure nanogram quantities of glucose. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method of measuring glucose on the skin comprising the steps of:
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wiping the skin surface with a wipe containing at least one solvent for removing glucose;
placing a patch on a skin surface, wherein the patch comprises a sweat-permeable membrane, and a collection layer, whereby the sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion; and
measuring glucose collected in the patch. - View Dependent Claims (37, 39)
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- 44. A patch comprising a sweat collection reservoir configured to collect glucose that has come to the skin surface via sweat, and a glucose detector capable of detecting nanogram quantities of glucose, wherein the patch is configured to operate with a measurement device for measuring the glucose.
Specification