Implantable apparatus having improved biocompatibility and process of making the same
First Claim
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1. A process to improve biocompatibility of an implantable apparatus, which comprises:
- exposing at least one surface of the implantable apparatus to a protein solution to form a layer of protein on the at least one surface;
fixing the protein layered implantable apparatus with a fixation solution; and
substantially detoxifying the fixed protein layer.
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Abstract
An implantable apparatus has a plurality of fixed and detoxified protein layers formed in situ overlying at least one surface to improve biocompatibility. A process of making the implantable apparatus can include repeatedly exposing at least one surface of the implantable apparatus to a protein solution to form a multi-layered coating of protein on the at least one surface and fixing the protein layered implantable apparatus with a fixation solution and then substantially detoxifying the multi-layered protein coating.
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Citations
29 Claims
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1. A process to improve biocompatibility of an implantable apparatus, which comprises:
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exposing at least one surface of the implantable apparatus to a protein solution to form a layer of protein on the at least one surface;
fixing the protein layered implantable apparatus with a fixation solution; and
substantially detoxifying the fixed protein layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for improving biocompatibility of an implantable article, the method comprising the steps of:
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exposing at least one surface of the implantable article to a protein solution so that the protein adheres to form a protein layer on the at least one surface;
cross-linking the protein layered implantable article with a fixation solution; and
performing heparin bonding to detoxify the implantable article and to help resist formation of thrombus on the implantable article. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. An implantable apparatus having improved biocompatibility, the apparatus comprising:
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at least one surface;
at least one layer of a fixed protein adhering to the at least one surface, the at least one layer of fixed protein having been formed by exposing the surface to a protein solution to form the at least one layer of protein and by fixing the at least one layer of the protein and by substantially detoxifying the fixed protein layer, which detoxification includes heparin bonding. - View Dependent Claims (20, 21, 22, 23, 24)
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25. An implantable apparatus having improved biocompatibility comprising:
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at least one surface; and
a plurality of protein layers formed in situ overlying the at least one surface, the plurality of layers having been fixed and substantially detoxified. - View Dependent Claims (26, 27, 28, 29)
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Specification