Methods of and pharmaceutical compositions for improving implantation of embryos
First Claim
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1. A method of improving embryo implantation, the method comprising contacting an embryo with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation, and implanting the embryo in a receptive uterus.
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Abstract
Methods of improving embryo implantation are disclosed and comprise contacting a receptive uterus and/or an embryo with an effective amount of heparanase and implanting the embryo in the receptive uterus.
101 Citations
50 Claims
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1. A method of improving embryo implantation, the method comprising contacting an embryo with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation, and implanting the embryo in a receptive uterus.
- View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of improving embryo implantation, the method comprising contacting a receptive uterus with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation and implanting the embryo in a receptive uterus.
- View Dependent Claims (8, 9, 10, 11, 12)
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13. A method of improving embryo implantation, the method comprising contacting a receptive uterus with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation, contacting an embryo with an effective amount of said heparanase and implanting the embryo in the receptive uterus.
- View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A method of improving IVF embryo implantation, the method comprising contacting an IVF embryo with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation, and implanting the embryo in a receptive uterus.
- View Dependent Claims (22, 23, 24, 25)
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26. A method of improving IVF embryo implantation, the method comprising contacting a receptive uterus with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation, and implanting the IVF embryo in the receptive uterus.
- View Dependent Claims (27, 28, 29, 30)
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31. A method of improving IVF embryo implantation, the method comprising contacting a receptive uterus with an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, so as to improve embryo implantation, contacting an IVF embryo with an effective amount of said heparanase and implanting the IVF embryo in the receptive uterus.
- View Dependent Claims (32, 33, 34, 35, 36, 37)
- 38. An embryo coated with exogenous purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
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42. A pharmaceutical composition comprising, as an active ingredient, an effective amount of isolated and purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, the pharmaceutical composition designed for intra-uterine application.
- View Dependent Claims (43, 44)
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45. A pharmaceutical composition comprising, as an active ingredient, an effective amount of purified heparanase, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
- 5, the pharmaceutical composition is designed for application to an embryo in vitro.
- View Dependent Claims (46, 47)
- 48. An embryo growth composition comprising an effective amount of nutrients for embryonic growth and an effective amount of purified heparanase for assisting in embryo implantation, said heparanase having or being activatable to have catalytic activity as an active form of a heparanase protein as set forth by SEQ ID NO:
Specification