Tricyclic inhibitors of poly(ADP-ribose) polymerases
First Claim
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1. A method of inhibiting activity of a PARP enzyme, comprising contacting the PARP enzyme with an effective amount of a compound of formula (I):
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Abstract
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease.
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12 Claims
- 1. A method of inhibiting activity of a PARP enzyme, comprising contacting the PARP enzyme with an effective amount of a compound of formula (I):
- 5. A method of inhibiting PARP enzyme activity in mammalian tissue by administering to a mammal a therapeutically effective amount of a compound of formula (I):
- 8. A method of potentiating cytotoxicity of a cytotoxic drug or ionizing radiation, comprising contacting cells with an effective amount of a compound of formula (I):
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