Methods and devices for occluding body lumens and/or enhancing tissue ingrowth

• US 20060009798A1
• Filed: 01/31/2005
• Published: 01/12/2006
• Est. Priority Date: 02/02/2004
• Status: Abandoned Application

• Current Assignee: Bayer Essure Inc. (Bayer AG)
• Original Assignee: Ams Research Corporation (Endo International PLC)
• Inventors: Tremulis, William S., Callister, Jeffrey P.
• Application Number:
  US11/048,221
• Publication Number:
  US 20060009798A1
• Time in Patent Office: Days
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/320008 Scrapers
• CPC Class Codes: A61F 6/225 transcervical

Abstract

The present invention provides devices, methods and systems for the occlusion of various lumens in a body of a patient including devices and methods for enhancing tissue ingrowth, particularly endothelial tissue growth within an occlusive device. The system includes an occlusive device and a delivery device for placing the occlusive device in a body lumen. The occlusive device is generally a tubular member with a mesh member disposed thereon. The occlusive device is configured to be radially expandable along a longitudinal axis of the tubular member and implantable with a delivery catheter such that the occlusive device is in a collapsed state when positioned in the delivery catheter and in an expanded state when positioned in a lumen of a patient. The mesh member of the occlusive device is configured to promote epithelial tissue ingrowth.

Claims

1. An occlusive device, said device comprising:

a first element constructed of a first metallic material; and

a second element constructed of a second metallic material, said first metallic material is different than said second metallic material, said first and second elements being electrically separated from each other along at least a significant portion of said elements.

2. An occlusive device as recited in claim 1 wherein said device comprises a stent and said elements comprise wires that form said combine to form at least part of said stent.

3. A stent as in claim 2 wherein at least one of said wires is gold.

4. A stent as in claim 2 wherein at least one of said wires contains iron.

5. An occlusive device as in claim 1 wherein said first element is contained within said second element.

6. An occlusive device as in claim 1 wherein at least one of said metallic elements is a helically shaped spring.

7. An occlusive device as in claim 6 wherein at least two of said elements are in the form of a helically shaped spring.

8. An occlusive device as in claim 6 wherein said first element is a helically shaped spring and said second element is a helically shaped spring, said first element being contained within said second element.

9. An occlusive device as in claim 6 wherein said first element is a helically shaped spring and said second element is a helically shaped spring, the coils of said first element and the coils of said second element being interspersed with each other.

10. An occlusive device as in claim 1 wherein the two metal elements are in the form of metal sheets coiled within each other.

11. An occlusive device for generating a galvanic action, said occlusive device comprising an elongate cylindrical, said device having metallic granules interspersed on or in said elongate cylindrical structure, said granules comprising at least two different metals.

12. A delivery catheter system for delivering an occlusive device into a body lumen comprising:

a tissue abrading distal tip portion comprising an abrasive portion of the outer wall of the distal end of the catheter; and

a pusher device for holding the occlusive device relative stationary in a longitudinal direction while the catheter is withdrawn which acts to expel the occlusive device from the catheter delivery lumen.

13. A delivery catheter system as in claim 12 further comprising a catheter region that has a first, retracted configuration and a second, expanded configuration, whereby the expanded configuration brings the abrasive region into contact with the lumen wall, and the retracted configuration withdraws the abrasive portion away from contact with the vessel wall.

14. A delivery catheter system as in claim 12 where the act of expelling the occlusive device acts to change the delivery catheter from the first configuration to the second configuration.

15. A delivery catheter system as in claim 12 further wherein when the occlusive device is fully expelled into the body lumen, the catheter returns to said first configuration.

16. A delivery catheter system as in claim 13 wherein said catheter outer surface is biased toward said first configuration, and requires application of force to move said catheter outer surface to said second configuration.

17. A delivery catheter system as in claim 14 wherein said abrasive out surface is elastically biased to said first configuration.

18. A delivery catheter system as in claim 14 where the catheter is changed from said first configuration to said second configuration by the occlusive device moving through said delivery lumen toward the open distal tip of said catheter.

19. A delivery catheter system as in claim 14 where the catheter is changed from said first configuration to said second configuration by the inflation of a balloon beneath the abrasive surface.

20. A delivery catheter system for delivering an occlusive device, said system comprising:

a catheter shaft;

a pusher wire contained within at least a portion of said catheter shaft, said pusher wire fixedly attached to said catheter handle; and

a handle having a sliding member and a catheter clasping member, said catheter clasping member attached to said sliding handle and to said catheter shaft such that moving said sliding member relative to said catheter handle serves to move said catheter shaft relative to said pusher wire.

21. A delivery catheter system as in claim 20 wherein said handle has an outer surface, and said slidable member slides along said outer surface, said outer surface comprising a surface feature that prevents sliding motion of said slidable member past said surface feature.

22. A delivery catheter system as in claim 21 where said surface feature is the head of a removable set screw.

23. A delivery catheter system as in claim 21 further comprising two set screws, wherein said slidalbe handle has a range of sliding motion, and said handle contains at least two surface features, said surface features located at different positions along said sliding range.

24. A delivery catheter system as in claim 20 further wherein said pusher wire is attached to a pusher element, said pusher element contained within a delivery lumen of said catheter near the distal end of said catheter, said delivery lumen further containing an occlusive device between said pusher element and said distal end of said delivery lumen, the proximal end of said occlusive device sized so that when the pusher element is moved longitudinally in said delivery lumen and contacts the proximal end of said occlusive device, it moves said occlusive device the same distance longitudinally as the pusher wire is moved after said contact thereby causing longitudinal movement of said occlusive device approximately equivalent to the longitudinal movement of said pusher wire.

25. A delivery catheter system as in claim 24 wherein a surface feature on the surface of said handle prevents further slideable motion after said slideable member contacts said surface element.

26. A delivery catheter system as in claim 25 wherein said surface feature is a first setscrew.

27. A delivery catheter system as in claim 26 wherein said first set screw is located such that the slideable motion is sufficient to expel the occlusive device out of the distal end of the delivery lumen of said catheter.

28. A delivery catheter system as in claim 27 further comprising a second set screw, said second set screw located so as to allow sufficient longitudinal relative motion between the catheter shaft and the pusher wire to cause the pusher element to move the occlusive device longitudinally toward the distal end of the delivery lumen but not allow sufficient longitudinal relative motion to permit the pusher to move the occlusive device out of the delivery lumen, and said first set screw is located to allow sufficient relative longitudinal motion between the pusher wire and the catheter shaft to allow the pusher to expel the occlusive device out of the distal end of the delivery lumen.

29. A delivery catheter comprising a catheter delivery lumen having a distal cone, said distal cone having a first, closed configuration and a second open configuration, said distal cone biased in the direction of said first, closed configuration, said distal cone being moved from said first closed configuration to said second, open configuration by movement of an occlusive device through said delivery lumen and out the distal end of said lumen, through the distal cone.

30. An occlusive device comprising:

a plurality of segments, said segments joined to the longitudinally adjacent segment by a flexible joining element such that not all the longitudinal force applied to one element is transmitted to the adjacent element.

31. An immediately effective occlusive device, the device comprising:

a barrier device, said barrier device substantially impermeable to the passage of cells within said body lumen; and

a scaffold device, said scaffold device permitting tissue ingrowth from the walls of said body lumen into said scaffold device such that an occlusion of said body lumen occurs when said tissue ingrowth has substantially occurred, and said scaffold device attached to said barrier device such that placement of said scaffold device into said body lumen places said barrier device and positions it in such a manner as to accomplish substantially complete occlusion of said body lumen.

32. An occlusive device as in claim 31 wherein said body lumen is the fallopian tube and said cells are egg cells.

33. An occlusive device as in claim 31 wherein said body lumen is the vas and said cells are sperm cells.

34. An occlusive device as in claim 31 wherein the scaffold is open celled foam and the barrier device is closed cell foam.

35. An occlusive device as in claim 31 wherein the occlusion device is formed of adjacent cylindrical lengths of foam, and the scaffold is open celled foam and the barrier device is closed cell foam.

36. An occlusive device as in claim 35 further comprising impermeable membrane forming the boundary between adjacent segments of said cylindrical foam.