Composite vascular graft including bioactive agent coating and biodegradable sheath
First Claim
1. A composite vascular graft comprising:
- a porous, flexible tubular graft member;
a biodegradable, bioactive agent coating layer disposed over said graft member;
said coating layer including at least one bioactive agent; and
a biodegradable sheath disposed over said coating layer, said sheath having a rigidity greater than said flexible tubular graft member; and
being biodegradable to expose said coating layer so as to re-establish the flexibility of said tubular graft member.
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Accused Products
Abstract
A composite vascular graft incorporates bioactive agents to deliver therapeutic materials and/or inhibit or reduce bacterial growth during and following the introduction of the graft to the implantation site in a vascular system. A composite vascular graft includes a porous tubular graft member. One or more biodegradable, bioactive agent coating layers are disposed over the graft member, the coating layer including at least one bioactive agent. A biodegradable sheath is disposed over the coating layer. The sheath has a rigidity greater than the flexible tubular graft member and is biodegradable to expose the coating layer so as to re-establish the flexibility of the tubular graft member.
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Citations
24 Claims
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1. A composite vascular graft comprising:
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a porous, flexible tubular graft member;
a biodegradable, bioactive agent coating layer disposed over said graft member;
said coating layer including at least one bioactive agent; and
a biodegradable sheath disposed over said coating layer, said sheath having a rigidity greater than said flexible tubular graft member; and
being biodegradable to expose said coating layer so as to re-establish the flexibility of said tubular graft member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of making a vascular graft for delivery of an antimicrobial agent associated therewith to a site of implantation of said graft, said method comprising the steps of:
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providing a porous, flexible tubular graft member;
applying a biodegradable coating material to said porous tubular graft member so as to form one or more overlying biodegradable, bioactive agent coating layers, said biodegradable coating material having at least one bioactive agent incorporated therein; and
disposing a biodegradable sheath over said one or more overlying coating layers. - View Dependent Claims (20, 21, 22, 23, 24)
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Specification