Laboratory animal housing with euthanizing function

• US 20060011143A1
• Filed: 07/14/2004
• Published: 01/19/2006
• Est. Priority Date: 07/14/2004
• Status: Abandoned Application

• Current Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center), Thoren Caging Systems, Inc.
• Original Assignee: Thoren Caging Systems, Inc.
• Inventors: Drummond, Robert A., Lipman, Neil S.
• Application Number:
  US10/890,726
• Publication Number:
  US 20060011143A1
• Time in Patent Office: Days
• US Class Current: 119/420
• CPC Class Codes: A01K 1/031 Cages for laboratory animals; Cages for measuring metabolism of animals
• CPC Class Codes: A22B 3/00 Slaughtering or stunning anaesthetising animals A61D7/04; cutting in general B26
• CPC Class Codes: A22B 3/005 by means of gas

Abstract

A high density animal housing system with an air source conduit and an air exhaust conduit is normally coupled to one or more ventilating animal cage racks through standard inlet/outlet fittings. A euthanasia fixture is coupled into the standard inlet/outlet fittings and selectively and sequentially operates valves and/or blowers to switch from supply of respiration air to a gas supply, to open and close the flow to the exhaust and to resume ventilation afterwards, for venting. The sequence is timed and controlled by a programmable controller that activates the associated blowers and valves automatically to follow a user selected sequence. The system anesthetizes and then euthanizes the animals via the same flow conduits that otherwise supply respiration air, requiring no rack modifications and little if any human attention other than to couple the rack to the ventilation system at the euthanasia fixture. Operator inputs allow selection among sequences. Status sensing inputs prevent initiation or continuation of a cycle in the event of certain faults.

Claims

1. An animal housing system comprising:

a ventilation system having an air source conduit and an air exhaust conduit for normally supplying air for respiration of animals;

a plurality of animal cages, each of the cages comprising an air impermeable material at least partly surrounding a housing area for the animals;

a support rack for the animal cages, configured such that when the cages are placed in said support rack, the animal cages are coupled between the air source and air exhaust conduits of the ventilation system, thereby supplying occupants of the animal enclosures with air for said respiration;

a supply of gas coupled to the air source conduit by a controllable valve, wherein the controllable valve is operable to displace at least part of said air for respiration, for at least one of anesthetizing and asphyxiating said animals while disposed in said cages in said support rack;

wherein the gas supply is external to the support rack and is activated by timed operation of the controllable valve.

2. The system of claim 1, wherein the cages comprise impermeable boxes suspended from hollow shelves with internal conduits coupled to said supply and exhaust conduits, and wherein the supply of gas is coupled between the ventilation system and the support rack.

3. The system of claim 1, wherein the supply of gas comprises pressurized CO₂ gas, and further comprising at least one valve for controllably coupling one of the respiration air and the supply of gas to the air source conduit.

4. The system of claim 3, further comprising a programmable controller coupled operate to the controllable valve, wherein the controller operates the valve in a series of successive operations.

5. The system of claim 4, wherein further comprising a timer coupled with the controller, for stepping through the series of successive operations in a timed sequence.

6. The system of claim 5, wherein the timed sequence is selected from among a plurality of user-selectable sequences.

7. The system of claim 4, further comprising at least one controllable blower coupled to at least one of the air source and air exhaust conduits, and wherein the controller is programmed to couple and decouple the controllable blower for controlling passage of air and gas to the exhaust conduit.

8. The system of claim 6, comprising a controllable supply blower, a controllable exhaust blower and at least one valve operable by the controller, wherein the controller is programmed to control said supply blower, exhaust blower and valve for coupling the respiration air and the gas exclusively to the air source conduit for a time, and for coupling and decoupling at least one of the supply blower and the exhaust blower, so as to effect a sequence of insufflation, soak and venting operations.

9. The system of claim 8, wherein the sequence of insufflation, soak and venting operations are timed to anesthetize and then asphyxiate the animals and then to discharge the gas.

10. The system of claim 8, wherein the controller is programmed to effect an insufflation phase wherein the supply of gas is substituted said air for respiration during a first time period, and a timed for distribution of the gas and a soak phase.

11. The system of claim 8, wherein the support rack is detachable from an existing set of air supply and air exhaust conduits and coupleable to a set of air supply and air exhaust conduits of a fixture in communication with the supply of gas and comprising said controllable valve.

12. A method of euthanizing laboratory animals, comprising:

housing the animals in a ventilated caging system wherein air supply and air exhaust conduits are coupled to plural substantially air impervious cage boxes containing animals, for passing a current into and through the cage boxes, the current initially containing respiration air with an oxygen concentration supporting respiration;

substituting for the air supply a source of gas, thereby displacing the respiration air in the current passing into the cage boxes, while continuing the current for a sufficient time substantially to insufflate the cage boxes with the gas, wherein said substitution is accomplished partly by coupling the source of gas between the ventilated caging system and the air supply, and partly by controlling the exhaust conduits;

halting the current for a predetermined time period after the cage boxes have been insufflated, whereupon the gas in the cage boxes asphyxiates the animals; and

,

resuming the current using respiration air, thereby flushing the gas the exhaust conduit;

wherein said substituting, halting and resuming steps include activating and deactivating outputs of a controller to automatically sequence operations of at least one of a valve and a blower affecting the current.