Method and device to recover diagnostic and therapeutic agents
First Claim
1. A method for recovering an agent introduced into a vascular inflow of an organ or tissue, comprising:
- inserting a distal end of a catheter into a vascular outflow of an organ or tissue, the catheter comprising a lumen, an outer surface, and an expandable occlusion device secured to the outer surface at the distal end to occlude a flow of fluid through the vascular outflow, while the lumen is in fluid communication with fluid in the vascular outflow;
occluding the flow of fluid through the vascular outflow by expanding the occlusion device; and
withdrawing or passively draining fluid from the vascular outflow through the lumen to recover at least a portion of an agent introduced into a vascular inflow of the organ or tissue.
1 Assignment
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Accused Products
Abstract
The invention relates to a method and device for recovering therapeutic and diagnostic agents from the venous outflow of a tissue or organ. A method for recovering an agent includes inserting a catheter into a vascular outflow of a tissue or organ, occluding the flow of blood/fluid through the vascular outflow, and withdrawing blood/fluid in the vascular outflow into the catheter to recover at least a portion of the agent administered to the vascular inflow of the organ or tissue. Also provided is a device to capture an agent administered to a vascular inflow, the device having a catheter having an expandable occlusion device to occlude a flow of fluid through the vascular outflow, a pump operably coupled to the catheter for withdrawing from the vascular outflow at least a portion of the agent administered to a vascular inflow of the organ or tissue, and an automated controller in signal communication with the catheter to control the expandable occlusion device and the pump to withdraw at least a portion of the agent from the vascular outflow.
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Citations
40 Claims
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1. A method for recovering an agent introduced into a vascular inflow of an organ or tissue, comprising:
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inserting a distal end of a catheter into a vascular outflow of an organ or tissue, the catheter comprising a lumen, an outer surface, and an expandable occlusion device secured to the outer surface at the distal end to occlude a flow of fluid through the vascular outflow, while the lumen is in fluid communication with fluid in the vascular outflow;
occluding the flow of fluid through the vascular outflow by expanding the occlusion device; and
withdrawing or passively draining fluid from the vascular outflow through the lumen to recover at least a portion of an agent introduced into a vascular inflow of the organ or tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of recovering contrast agent during a coronary angiography, comprising:
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inserting a catheter into a coronary sinus, the catheter comprising a lumen, an outer surface, a proximal end and a distal end, and an expandable occlusion device secured to the outer surface of the lumen at the distal end to occlude a flow of fluid through a coronary sinus while the lumen is in fluid communication with fluid in the coronary sinus;
introducing a contrast agent into a coronary artery;
expanding the occlusion device to occlude the flow of fluid through the coronary sinus; and
withdrawing fluid from the coronary sinus into the lumen to recover at least a portion of the contrast agent introduced into the coronary artery. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. An apparatus to capture an agent introduced into a vascular inflow of an organ or tissue, comprising:
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a catheter comprising a lumen, an outer surface, a proximal end and a distal end, the distal end being insertable into a vascular outflow of an organ or tissue, and an expandable occlusion device secured to the outer surface at the distal end to occlude a flow of fluid through the vascular outflow;
a pump, connected to the catheter, configured and arranged to withdraw fluid from the vascular outflow into the lumen; and
an automated controller in signal communication with the catheter to control the expandable occlusion device to occlude the flow of fluid through the vascular outflow, and to control the pump to withdraw at least a portion of the agent from the vascular outflow, the controlling of the occlusion device and the pump based on at least the timing of the agent administered into the vascular inflow. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A device to capture a contrast agent introduced into a coronary artery during a coronary angiography, comprising:
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a catheter comprising a lumen, an outer surface, a proximal end and a distal end, the distal end being insertable into a coronary sinus, and an inflatable balloon secured to the outer surface at the distal end to occlude a flow of fluid in the coronary sinus;
a pump, operably coupled to the catheter, configured and arranged to withdraw fluid from the coronary sinus into the lumen; and
an automated controller in signal communication with the catheter to control the inflatable balloon to occlude the flow of fluid in the coronary sinus, and to control the pump to withdraw at least a portion of the agent from the vascular outflow, the controlling of the occlusion device and the pump based on timing and rate of introduction of an agent introduced into the vascular inflow. - View Dependent Claims (40)
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Specification