Functional foods comprising flavonoids and tocotrienols and methods thereof

• US 20060013861A1
• Filed: 05/24/2005
• Published: 01/19/2006
• Est. Priority Date: 05/26/2004
• Status: Abandoned Application

• Current Assignee: KGK Synergize Incorporated
• Original Assignee: KGK Synergize Incorporated
• Inventors: Guthrie, Najla
• Application Number:
  US11/135,675
• Publication Number:
  US 20060013861A1
• Time in Patent Office: Days
• US Class Current: 424/439
• CPC Class Codes: A23C 15/00 Butter; Butter preparations; Making thereof butter substitutes A23D
• CPC Class Codes: A23C 9/13 using additives
• CPC Class Codes: A23C 9/152 containing additives fermented milk preparations containing additives A23C9/13
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 33/11 Plant sterols or derivatives thereof, e.g. phytosterols
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/326 having effect on cardiovascular health
• CPC Class Codes: A23V 2200/3262 having an effect on blood cholesterol
• CPC Class Codes: A23V 2250/21 Plant extracts
• CPC Class Codes: A23V 2250/2116 Flavonoids, isoflavones
• CPC Class Codes: A23V 2250/21164 Hesperidin
• CPC Class Codes: A23V 2250/712 Vitamin E
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 36/752 Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Disclosed in certain embodiments is a functional food comprising an active agent combination comprising flavonoids and tocotrienols.

Claims

1. A functional food comprising an edible solid or liquid;

and an active agent combination comprising polymethoxylated flavonoids and tocotrienols.

2. The functional food according to claim 1, wherein the active agent combination comprises flavonoids and tocotrienols in a ratio of about 75:

25 to about 95;

5.

3. The functional food according to claim 1, wherein the active agent combination comprises flavonoids and tocotrienols in a ratio of about 90:

10.

4. The pharmaceutical ingredient according to claim 1, wherein the active agent combination comprises flavonoids and tocotrienols in a ratio of about 80:

20.

5. The functional food according to claim 1, wherein the flavonoid comprises a member consisting of naringenin, hesperetin, nobiletin, and tangeretin.

6. The functional food according to claim 1, wherein the tocotrienol is selected from the group consisting of alpha-tocotrienol, gamma-tocotrienol, and delta-tocotrienol.

7. The functional food of claim 1, wherein the active agent combination is derived from a member selected from the group consisting of an essence oil isolated from a citrus fruit, a peel oil isolated from a citrus fruit, a peel isolated from a citrus fruit, decharacterized citrus fruit, and combinations thereof.

8. The functional food of claim 1, wherein the combination is in an effective amount to treat a human subject at risk of or suffering from a cardiovascular disease.

9. The functional food of claim 10, wherein the cardiovascular disease is hypercholesterolemia or atherosclerosis.

10. The functional food according to claim 1, in the form of a chewable or edible bar, a confectionary product, a cookie, a juice drink, a puree, a baked or simulated baked good, a biscuit, a lozenge or chewing gum.

11. The functional food according to claim 1, in the form of a brownie or a chocolate bar.

12. The functional food according to claim 1, in the form of butter, margarine, bread, cake, a milk shake, ice cream, yogurt or other fermented milk product.

13. The functional food according to claim 1, in the form of a powder or a cereal.

14. The functional food according to claim 1, comprising from about 10 mg to about 80 mg of the tocotrienol and from about 150 mg to about 750 mg of the flavonoid per serving.

15. The functional food according to claim 1, comprising about 30 mg of the tocotrienol and about 270 mg of the flavonoid per serving.

16. The functional food according to claim 1, comprising about 60 mg of the tocotrienol and about 560 mg of the flavonoid per serving.

17. The functional food according to claim 1, wherein the functional food lowers total cholesterol by at least 10%.

18. The functional food according to claim 17, wherein the functional food lowers total cholesterol by at least 10% in a single patient.

19. The functional food according to claim 17, wherein the functional food lowers total cholesterol by at least 10% in a patient population.

23. The functional food according to claim 17, wherein the functional food lowers total cholesterol by at least 10% after administration for 4 weeks.

26. The functional food according to claim 1, wherein the functional food lowers triacylglycerols by at least 15%.

27. The functional food according to claim 26, wherein the functional food lowers triacylglycerols by at least 15% in a single patient.

28. The functional food according to claim 26, wherein the functional food lowers triacylglycerols by at least 15% in a patient population.

35. The functional food according to claim 1, wherein the functional food lowers LDL cholesterol by at least 10%.

36. The functional food according to claim 35, wherein the functional food lowers LDL cholesterol by at least 10% in a single patient.

37. The functional food according to claim 35, wherein the functional food lowers LDL cholesterol by at least 10% in a patient population.

44. The functional food according to claim 1, wherein the functional food lowers Apo B by at least 10%.

45. The functional food according to claim 44, wherein the functional food lowers Apo B by at least 10% in a single patient.

46. The functional food according to claim 44, wherein the functional food lowers Apo B by at least 10% in a patient population.

53. The functional food of claim 1, further comprising an additional active agent selected from the group consisting of soy protein, soy isoflavones, grapeseed extract, pine bark extract, gugulipids, policosinols, pantesine, niacin, alpha lipoic acid, tea flavins, coenzyme q10, lutein, statins, and combinations thereof.

54. A method of treating a human subject at risk of or suffering from cardiovascular disease comprising administering an effective amount of a functional food according to claim 1.

55. The method of claim 54, wherein the cardiovascular disease is hypercholesterolemia or atherosclerosis.

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