Insulin resistance improving agents
First Claim
1. An insulin-sensitizing agent which comprises a compound or its salt that inhibits the activity of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
1 Assignment
0 Petitions
Accused Products
Abstract
A compound or its salt inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, an extracellular domain of the protein above, an antibody, an antisense polynucleotide, etc. are usable as insulin-sensitizing agents and preventives and/or remedies for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension, heart disease, and so on.
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Citations
48 Claims
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1. An insulin-sensitizing agent which comprises a compound or its salt that inhibits the activity of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
- View Dependent Claims (4)
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2. An insulin-sensitizing agent which comprises a compound or its salt that inhibits the expression of a gene for a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1.
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3. An insulin-sensitizing agent which comprises a compound or its salt that inhibits the expression of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1.
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5. An insulin-sensitizing agent which comprises an extracellular domain of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1;
or a salt thereof. - View Dependent Claims (6)
- 1;
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7. An agent for the prevention, treatment, or combination thereof, of diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises an extracellular domain of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1;
or a salt thereof.
- 1;
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8. An antisense polynucleotide containing the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1 or its partial peptide.
- View Dependent Claims (9, 10)
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11. An insulin-sensitizing agent which comprises an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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12. An agent for the prevention, treatment, or combination thereof, of diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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13. A diagnostic agent for insulin resistance, which comprises an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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14. A diagnostic agent for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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15. A diagnostic agent for insulin resistance, which comprises a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
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16. A diagnostic agent for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
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17. A method of screening an insulin-sensitizing agent, which comprises using a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
- View Dependent Claims (24)
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18. A method of screening an antagonist of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or a salt of the protein, which comprises using (i) the protein, its partial peptide, or a salt thereof and (ii) a ligand to the protein, its partial peptide, or a salt thereof.
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19. A method of screening an insulin-sensitizing agent, which comprises using (i) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof and (ii) a ligand to the protein, its partial peptide, or a salt thereof.
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20. A kit for screening an insulin-sensitizing agent, which comprises a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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21. A method of screening an insulin-sensitizing agent, which comprises using a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
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22. A kit for screening an insulin-sensitizing agent which comprises a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
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23. (canceled)
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25. A method of screening an agent for the prevention, treatment, or combination thereof, of diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises using a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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26. A kit for screening an agent for the prevention, treatment, or combination thereof, of diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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27. A method of screening an agent for the prevention, treatment, or combination thereof, of diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises using a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
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28. A kit for screening an agent for the prevention, treatment, or combination thereof, of diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, or its partial peptide.
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29-33. -33. (canceled)
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34. A method of improving insulin resistance, which comprises administering to a mammal an effective amount of a compound or its salt that inhibits the activity of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt of the protein.
- View Dependent Claims (37)
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35. A method of improving insulin resistance, which comprises administering to a mammal an effective amount of a compound or its salt that inhibits the expression of a gene for a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1 or its partial peptide.
- View Dependent Claims (38)
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36. A method of improving insulin resistance, which comprises administering to a mammal an effective amount of a compound or its salt that inhibits the expression of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1 or its partial peptide.
- View Dependent Claims (39)
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40. A method of improving insulin resistance, which comprises administering to a mammal an effective amount of an extracellular domain of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1;
or a salt thereof. - View Dependent Claims (41)
- 1;
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42. A method of preventing and/or treating diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises administering to a mammal an effective amount of an extracellular domain of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1;
or a salt thereof. - View Dependent Claims (43, 44)
- 1;
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45. A method of improving insulin resistance, which comprises administering to a mammal an effective amount of an antisense polynucleotide containing the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding a protein containing the same or substantially the same amino acid sequence represented by SEQ ID NO:
- 1 or its partial peptide.
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46. A method of improving insulin resistance, which comprises administering to a mammal an effective amount of an antibody to a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt thereof.
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47. A method of improving insulin resistance, which comprises inhibiting (i) the activity of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt of the protein, (ii) the expression of a gene for the protein or its partial peptide or (iii) the expression of the protein or its partial peptide.
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48. A method of preventing and/or treating diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension or heart disease, which comprises inhibiting (i) the activity of a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
- 1, its partial peptide, or a salt of the protein, (ii) the expression of a gene for the protein or its partial peptide or (iii) the expression of the protein or its partial peptide.
Specification