Pharmaceutical compositions for prevention of overdose or abuse
First Claim
Patent Images
1. A compound of the formula:
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A-Xm-Zn wherein A is an active agent;
X is a linker covalently bound to A; and
Z is an amino acid, peptide, or oligopeptide covalently bound to x, wherein m and n range from 1 to 50.
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Accused Products
Abstract
The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause overdose or to be abused. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.
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Citations
47 Claims
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1. A compound of the formula:
A-Xm-Znwherein A is an active agent;
X is a linker covalently bound to A; and
Z is an amino acid, peptide, or oligopeptide covalently bound to x, wherein m and n range from 1 to 50. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22)
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21. (canceled)
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23-24. -24. (canceled)
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25. A compound of the formula:
A-Xm-Znwherein A is a drug radical;
X is a small linear or cyclic molecule containing 2-6 atoms with one or more heteroatoms and one or more functional groups, wherein X is bonded to A through a carboxyl group; and
Z is an amino acid, peptide, or oligopeptide covalently bound to X, wherein m and n range between 1 and 50.
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26-45. -45. (canceled)
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46. A compound comprising a drug radical covalently bonded to a first amino acid selected from the group consisting of Ser, Lys, Glu, Asp, Ala, Leu, Phe, Val, Gly, Tyr, Pro, and Thr, and a second amino acid or peptide covalently bonded to the first amino acid, wherein an optional linker attaches the first amino acid to the drug radical.
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47-61. -61. (canceled)
Specification