Angiogenic compounds and uses thereof
First Claim
Patent Images
1. A compound of Formula I or a salt thereof, wherein R is a linear or branched, saturated or unsaturated one to 15 carbon alkyl group;
- X, Y, and Z are independently selected from the group consisting of H, OH, and OSO3−
; and
at least one of X, Y, or Z is OSO3−
;
provided that the compound does not have the precise structure of any of the structures listed in Tables I or II.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention provides sterol sulphate compounds and compositions that are capable of promoting angiogenesis. The invention also provides methods and uses for these compounds.
-
Citations
38 Claims
-
1. A compound of Formula I or a salt thereof,
wherein R is a linear or branched, saturated or unsaturated one to 15 carbon alkyl group; -
X, Y, and Z are independently selected from the group consisting of H, OH, and OSO3−
; and
at least one of X, Y, or Z is OSO3−
;
provided that the compound does not have the precise structure of any of the structures listed in Tables I or II. - View Dependent Claims (2, 3, 4, 5, 6, 10)
-
-
7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and one or more compounds of Formula I or pharmaceutically acceptable salts thereof,
wherein R is a linear or branched, saturated or unsaturated one to 15 carbon alkyl group; -
X, Y, and Z are independently selected from the group consisting of H, OH, and OSO3−
; and
at least one of X, Y, or Z is OSO3−
. - View Dependent Claims (8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
-
20. A method of promoting angiogenesis or promoting proliferation or sprouting of endothelial cells, comprising administering an amount of one or more compounds of Formula I or pharmaceutically acceptable salts thereof,
wherein R is a linear or branched, saturated or unsaturated one to 15 carbon alkyl group; -
X, Y, and Z are independently selected from the group consisting of H, OH, and OSO3−
; and
at least one of X, Y, or Z is OSO3−
, andwherein said amount is sufficient to promote angiogenesis or to promote proliferation or sprouting of endothelial cells. - View Dependent Claims (21, 22, 23, 24, 25)
-
-
26. A method of treating or preventing a disorder associated with sub-optimal angiogenesis, comprising administering an effective amount of one or more compounds of Formula I or pharmaceutically acceptable salts thereof,
wherein R is a linear or branched, saturated or unsaturated one to 15 carbon alkyl group; -
X, Y, and Z are independently selected from the group consisting of H, OH, and OSO3−
; and
at least one of X, Y, or Z is OSO3−
; and
wherein said amount is sufficient to treat or prevent the disorder associated with sub-optimal angiogenesis. - View Dependent Claims (27, 28, 29, 30, 31, 32)
-
- 33. A method of identifying a sterol sulphate compound that is capable of promoting angiogenesis, the method comprising screening the compound for activity in promoting angiogenesis.
Specification