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Optical apparatus and method of use for non-invasive tomographic scan of biological tissues

  • US 20060015021A1
  • Filed: 06/29/2004
  • Published: 01/19/2006
  • Est. Priority Date: 06/29/2004
  • Status: Active Grant
First Claim
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1. A method for quantifying at least one of scattering property, absorption coefficient or chromophore concentrations of a physical medium, said method comprising the steps of:

  • (a) introducing into said physical medium, at a first site, an input modulated signal with a modulation frequency (Fn);

    (b) detecting, at a second site, an output modulated signal migrated over a migration path in said physical medium from said input modulated signal;

    (c) comparing said output modulated signal with said input modulated signal and measuring therefrom a phase shift (φ

    ) between said input modulated signal and said output modulated signal;

    (e) repeating steps (a)-(c) at two or more modulation frequencies and calculating average scattering property and absorption coefficient of said physical medium using the following equation;

    ϕ

    =(

    n=01


    an

    μ

    s





    n
    )


    μ

    a-1
    +(

    n=02


    bn

    μ

    s





    n
    )


    μ

    a-0.5
    +

    n=01


    cn

    μ

    s





    n
    wherein μ

    a is the absorption coefficient, μ

    s is the effective scattering property of said physical medium, an, bn, and cn, are parameters determined by said modulation frequency (Fn) and a distance (D) between said first site and said second site using a fitting algorithm.

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