Agents and methods for enhancement of transdermal transport
First Claim
1. A method for transporting a substance across a biological membrane comprising:
- applying a delipidation agent to a portion of the biological membrane;
applying a hydration agent to the portion of the biological membrane;
sonicating the portion of the biological membrane; and
transporting the substance across the biological membrane.
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Accused Products
Abstract
The invention according to an exemplary embodiment relates to a method for transporting a substance across a biological membrane comprising the steps of applying a delipidation agent to a portion of the biological membrane, applying a hydration agent to the portion of the biological membrane, sonicating the portion of the biological membrane, and transporting the substance across the biological membrane. The step of applying the delipidation agent may be carried out prior to or simultaneously with the step of applying the hydration agent. The hydration agent may be applied before, during, or after the sonication step. The methods according to exemplary embodiments of the invention can provide improved transdermal transport in applications such as continuous analyte extraction and analysis and transdermal delivery of drugs and vaccines.
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Citations
68 Claims
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1. A method for transporting a substance across a biological membrane comprising:
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applying a delipidation agent to a portion of the biological membrane;
applying a hydration agent to the portion of the biological membrane;
sonicating the portion of the biological membrane; and
transporting the substance across the biological membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of transporting a substance across a biological membrane comprising:
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providing a biological membrane exposed to a first pressure;
sonicating a portion of the biological membrane;
changing the pressure over the portion of the biological membrane to a second pressure after sonicating the portion of the biological membrane; and
transporting the substance across the biological membrane. - View Dependent Claims (24, 25, 26, 27)
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- 28. A method of preparing a biological membrane for transdermal transport of an agent comprising treating the biological membrane with a hydrating agent before, after, or both before and after sonicating the biological membrane.
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31. A method of preparing a biological membrane for sonication comprising treating the biological membrane with a solution comprising alcohol, Lippo Gel, bile salt, or glycerol prior to sonication.
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32. A method for sampling and analysis of an analyte from a body fluid in a patient comprising:
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increasing a permeability level of an area of a biological membrane of the patient;
applying a transport force to the area to extract the analyte from the body fluid in the patient through the area and into a medium;
continuously reacting the analyte in the medium to produce an electrical signal at an electrode adjacent to the medium, the electrical signal representing a rate of reaction of the analyte; and
calculating an analyte concentration in the body fluid in the patient based on the electrical signal.
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33. A system for sampling and analysis of an analyte from a body fluid in a patient comprising:
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an ultrasonic applicator that applies ultrasound to an area of a biological membrane of the patient;
a medium comprising a substance that reacts with the analyte;
an electrode positioned adjacent to the medium, the electrode being adapted to receive an electrical signal produced by the reaction of the analyte with the substance in the medium, the electrical signal representing a rate of reaction of the analyte with the substance; and
a processor electrically connected to the electrode;
wherein the processor is programmed to continuously calculate a concentration of the analyte in the body fluid of the patient based on the electrical signal.
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34. A transdermal analyte monitoring system comprising:
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a sensor body;
a medium supported by the sensor body and adapted to interface with a biological membrane, wherein the medium is adapted to prevent accumulation of analytes and analyte indicators during operation; and
an electrode adapted to detect the presence of an analyte within the medium.
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35. A method for transdermal analyte monitoring comprising the steps of:
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providing a sensor body, a medium and an electrode;
positioning the medium adjacent to the surface of a biological membrane; and
monitoring a flux of the analyte through the biological membrane using the electrode. - View Dependent Claims (36, 37, 38)
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39. A transdermal analyte monitoring system comprising:
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a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane; and
an electrode assembly comprising a plurality of electrodes;
wherein the medium is adapted to react continuously with the analyte; and
wherein an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47)
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48. A transdermal analyte monitoring system comprising:
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a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane; and
a sensor comprising an electrode assembly, the electrode assembly comprising a plurality of electrodes;
wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. - View Dependent Claims (49, 50)
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51. A method for monitoring an analyte comprising:
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positioning a medium with respect to a biological membrane such that the medium can receive an analyte from the biological membrane;
coupling an electrode assembly to the medium, the electrode assembly comprising a plurality of electrodes; and
continuously reacting the analyte with the medium;
wherein an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. - View Dependent Claims (52, 53)
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54. A cartridge for use with a sonication device comprising:
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a cartridge body adapted for insertion into the sonicating device; and
a chamber within the cartridge body, wherein the chamber contains cavitation fluid comprising a hydrating agent. - View Dependent Claims (55, 56, 57, 58, 59, 60)
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61. A kit for use with a sonication device comprising:
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an ultrasonic coupling medium cartridge adapted to interface with the sonication device; and
a skin preparation pad, wherein the skin preparation pad comprises a hydrating agent. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68)
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Specification