Bispecific antibodies
First Claim
Patent Images
1. A composition, the composition comprising a polypeptide comprising a cardiac antigen-specific binding component and a stem cell antigen-specific binding component, wherein the cardiac antigen-specific binding component comprises a polypeptide that specifically binds to a cardiac antigen available for binding to the cardiac antigen-specific binding component, wherein the cardiac antigen is selected from the group consisting of:
- myosin light chain and troponin I; and
wherein the stem cell antigen-specific component comprises a polypeptide that specifically binds to an antigen expressed on the surface of a stem cell.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides compositions and methods for targeting stem cells to injured cardiac tissue.
-
Citations
25 Claims
-
1. A composition, the composition comprising a polypeptide comprising a cardiac antigen-specific binding component and a stem cell antigen-specific binding component,
wherein the cardiac antigen-specific binding component comprises a polypeptide that specifically binds to a cardiac antigen available for binding to the cardiac antigen-specific binding component, wherein the cardiac antigen is selected from the group consisting of: - myosin light chain and troponin I; and
wherein the stem cell antigen-specific component comprises a polypeptide that specifically binds to an antigen expressed on the surface of a stem cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- myosin light chain and troponin I; and
-
12. A method for targeting stem cells to injured cardiac tissue, the method comprising:
-
administering a composition to a subject, said composition comprising a polypeptide comprising a cardiac antigen-specific binding component and a stem cell antigen-specific binding component, wherein the cardiac antigen-specific binding component comprises a polypeptide that specifically binds to a cardiac antigen available for binding to the first component, wherein the cardiac specific antigen is selected from the group consisting of;
myosin light chain and troponin I;
wherein the stem cell antigen-specific binding component comprises a polypeptide that specifically binds to an antigen expressed on the surface of a stem cell; and
wherein the polypeptide is bound to the stem cell. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. Use, in the manufacture of a medicament for targeting stem cells to injured cardiac tissue of a polypeptide comprising a cardiac antigen-specific binding component and a stem cell antigen-specific binding component,
wherein the cardiac antigen-specific binding component comprises a polypeptide that specifically binds to a cardiac-specific antigen available for binding to the first component, wherein the cardiac specific antigen is selected from the group consisting of: - myosin light chain and troponin I; and
wherein the stem cell antigen-specific binding component comprises a polypeptide that specifically binds to an antigen expressed on the surface of a stem cell. - View Dependent Claims (23, 24, 25)
- myosin light chain and troponin I; and
Specification