Design of therapeutics and therapeutics
First Claim
Patent Images
1. A therapeutic complex, selected from among:
- (a) a therapeutic complex, comprising;
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a subject-specific target;
the effector molecule renders the resulting therapeutic complex biologically effective;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is conjugated to the targeting domain; and
the capture agent is conjugated to the effector molecule;
(b) therapeutic complex, comprising;
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a target;
the effector molecule is a polypeptide and renders the resulting therapeutic complex biologically effective;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is a polypeptide between 5 and 100 amino acids in length;
the binding partner is conjugated to the targeting domain;
the capture agent is conjugated to the effector molecule; and
(c) a therapeutic complex, comprising;
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a target;
the effector molecule renders the resulting therapeutic complex biologically effective, wherein the biological effect of the therapeutic complex is selected from the group consisting of an immunomodulatory effect and an apoptotic effect;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is conjugated to the targeting domain; and
the capture agent is conjugated to the effector molecule.
2 Assignments
0 Petitions
Accused Products
Abstract
Therapeutic complexes and components of therapeutic complexes are provided herein. Also provided are methods of preparing therapeutic complexes and methods of administering therapeutic complexes.
152 Citations
77 Claims
-
1. A therapeutic complex, selected from among:
-
(a) a therapeutic complex, comprising;
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a subject-specific target;
the effector molecule renders the resulting therapeutic complex biologically effective;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is conjugated to the targeting domain; and
the capture agent is conjugated to the effector molecule;
(b) therapeutic complex, comprising;
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a target;
the effector molecule is a polypeptide and renders the resulting therapeutic complex biologically effective;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is a polypeptide between 5 and 100 amino acids in length;
the binding partner is conjugated to the targeting domain;
the capture agent is conjugated to the effector molecule; and
(c) a therapeutic complex, comprising;
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a target;
the effector molecule renders the resulting therapeutic complex biologically effective, wherein the biological effect of the therapeutic complex is selected from the group consisting of an immunomodulatory effect and an apoptotic effect;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is conjugated to the targeting domain; and
the capture agent is conjugated to the effector molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
-
-
68. A therapeutic complex, comprising:
-
a targeting domain and an effector molecule, wherein;
the targeting domain specifically binds to a target;
the effector molecule renders the resulting therapeutic complex biologically effective;
the targeting domain and effector molecule are linked via the specific interaction of a binding partner and a capture agent;
the binding partner is conjugated to the targeting domain;
the capture agent is conjugated to the effector molecule; and
the capture agent comprises at least one variable domain of an antibody or a portion thereof sufficient to specifically bind to the binding partner. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76, 77)
-
Specification