Biosensor with rf signal transmission

• US 20060019373A1
• Filed: 12/08/2003
• Published: 01/26/2006
• Est. Priority Date: 12/09/2002
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Kahlman, Josephus Arnoldus Henricus Maria, Prins, Menno Willem Jose, Van Houten, Hendrik
• Application Number:
  US10/536,637
• Publication Number:
  US 20060019373A1
• Time in Patent Office: Days
• US Class Current: 435/287.200
• CPC Class Codes: G01N 2291/0256 Adsorption, desorption, surface mass change, e.g. on biosensors
• CPC Class Codes: G01N 2291/0423 Surface waves, e.g. Rayleigh waves, Love waves
• CPC Class Codes: G01N 2291/0426 Bulk waves, e.g. quartz crystal microbalance, torsional waves
• CPC Class Codes: G01N 2446/00 Magnetic particle immunoreagent carriers
• CPC Class Codes: G01N 27/745 for detecting magnetic beads used in biochemical assays concerning the assays G01N33/54326; sensors therefor G01R33/1269; automatic analysers therefor G01N35/0098
• CPC Class Codes: G01N 29/022 Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices microdevices per se B81B
• CPC Class Codes: G01N 29/036 by measuring frequency or resonance of acoustic waves
• CPC Class Codes: G01N 33/48792 Data management, e.g. communication with processing unit for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C

Abstract

A device (1) and method for measuring and or detecting the presence of biomolecules. The device comprises a resonance circuit arranged to operate and emit a resonance frequency (f). The resonance circuit comprises or is coupled to a sensor element (5) for detecting the binding of biomolecules (6a) to binding sites (5a). The binding of the biomolecules changes a physical property (R, L, C. mass) of the sensor element (5), which in it'"'"'s turn, either directly when the sensor element forms part of the resonance circuit, or via a coupling of the sensor element to the resonance circuit, the resonance frequency. The change in the resonance frequency is detected. The device comprises a remote power transmission element, such as a photodiode or coil, for providing power to the resonance circuit using light or RF radiation respectively.

Claims

1. A device (1) comprising a sensor element (5, 31, 32, 33, 71) having biomolecular binding sites (5a) for a biomolecule (6a), characterised in that the device (1) comprises:

a remote power transmission element (3, 101), a resonance circuit, said resonance circuit comprising an resonance frequency determining sensor element (5, 31, 32,) or being electrically coupled to a resonance frequency determining sensor element (33, 71), wherein binding at the binding sites (5a) effects a physical property (R, L, C, mass) of the sensor element (5, 31, 32, 33, 71) and thereby the resonance frequency (f), and a circuit for RF communication of an RF signal (RF) in dependence of the resonance frequency of the resonance circuit.

2. A device as claimed in claim 1, characterised in that the remote power transmission element comprises a photodiode (3).

3. A device as claimed in claim 1, characterised in that the remote power transmission element comprises a coil (101) for receiving RF power whereby the remote power transmission element is arranged for receiving an RF frequency different from the resonance frequency.

4. A device as claimed in claim 1, characterised in that the sensor element (5, 31, 32) forms a part of the resonance frequency circuit.

5. A device as claimed in claim 4, characterised in that the sensor element (33, 71) forms part of a voltage or current supplying circuit, coupled to the resonance circuit, wherein the voltage (V) or current (I) of the supplying circuit is dependent on a physical property (R) of the sensor element, and the resonance frequency (f) of the resonance circuit is dependent on said voltage (V) or current (I).

6. A device as claimed in claim 1 or 4, characterised in that the sensor element (71) is a GMR magnetoresistive element

7. A device as claimed in claim 3 or 4, characterised in that the sensor elements are resistive elements provided in a bridge configuration.

8. A device as claimed in claim 2, characterised in that the sensors elements are located on the surface of an on-chip SAW/BAW (Surface Acoustic Wave/Bulk Acoustic Wave) resonator which is part of the oscillator circuit.

12. A system for detecting biomolecules in samples provided on a biosensor device, which system comprises the biosensor device and a reader station comprising a power transmitting element for transmitting power to the biosensor device and an antenna and a receiver for receiving of signals to be wirelessly transmitted from the biosensor device to the reader station with a transmitting frequency, characterized in that:

a device as claimed in any of the claims 1 to 8 is present,

the apparatus comprises or is connected to an analyser for analysing the transmitting frequency of the signal of the biosensor device or the change thereof with respect to a calibration frequency.

9. A method for detecting biomolecules in samples using a device (1) comprising a sensor element (5, 31, 32, 33, 71) having biomolecular binding sites (5a) for a biomolecule, characterised in that a sensor device is used comprising a remote power transmission element (3), a resonance circuit comprising an resonance frequency determining sensor element (5, 31, 32), or being electrically coupled to a resonance frequency determining sensor element (33, 71), wherein binding at the bonding sites effects a physical property of the sensor element (5, 31, 32, 33, 71) and thereby the resonance frequency, and a circuit for RF communication of an RF signal in dependence of the resonance frequency, the method comprising the steps of:

a) Binding a target to binding sites of the sensor element

b) Remotely sending power to the remote power transmission element for powering the biosensor device

c) recording the RF signal emitted by the circuit for RF communication.

10. A method as claimed in claim 9, characterised in that the remote power transmission element comprises a photodiode (3) and in step b light (2) is shone on the photodiode.

11. A method as claimed in claim 9, characterised in that the remote transmission element comprises a coil (101) for receiving RF power whereby the remote power transmission element is arranged for receiving an RF frequency different from the resonance frequency and in step b an RF frequency corresponding to the RF frequency of the remote power transmission element is emitted.

13. A reader station comprising:

a power transmitting element for transmitting power to a biosensor device;

an antenna and a receiver for receiving of signals to be wirelessly transmitted from the biosensor device to the reader station with a transmitting frequency, and

an analyser for analysing the transmitting frequency of the signal of the biosensor device or the change thereof with respect to a calibration frequency.