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Porous plasma protein matrices and methods for preparation thereof

  • US 20060019389A1
  • Filed: 07/22/2004
  • Published: 01/26/2006
  • Est. Priority Date: 07/22/2004
  • Status: Active Grant
First Claim
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1. A porous, freeze-dried plasma protein matrix comprising plasma proteins and thrombin, having two opposing surfaces substantially parallel to the horizontal axis of the matrix and at least one additional surface extending along the periphery of the sponge substantially parallel to the vertical axis, wherein the plasma proteins crosslinked by the action of thrombin are present in a gradient having a higher concentration along one of the opposing surfaces and, wherein the average size of the pores in cross section is smaller along the surface of the matrix exposed to the higher concentration of thrombin.

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