Factor VIIa variants
First Claim
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1. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with a cysteine amino acid.
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Abstract
Novel compounds are provided which modulate a FVIIa mediated or associated process or event such as the catalytic conversion of FX to FXa, FVII to FVIIa or FIX to FIXa. In particular aspects, the compounds of the invention are variants of Factor VIIa (FVIIa). Pharmaceutical compositions are also provided which comprise the novel compounds as well as their use in diagnostic, therapeutic, and prophylactic methods.
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Citations
28 Claims
- 1. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with a cysteine amino acid.
- 11. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with an amino acid that locks A2-strand of FVIIa to B2-strand of FVIIa.
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15. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with a cysteine amino acid, which correspond to a human amino acid residue pair S136 and V160.
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16. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with a cysteine amino acid, which correspond to a human amino acid residue pair L137 and N159.
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17. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with a cysteine amino acid, which correspond to a human amino acid residue pair V138 and V160.
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18. A Factor VIIa (FVIIa) variant comprising an amino acid sequence derived from a mammalian FVIIa protein, wherein at least two amino acid residues are substituted with a cysteine amino acid, which correspond to a human amino acid residue pair S139 and V157.
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