Method of drug delivery to interstitial regions of the myocardium
First Claim
Patent Images
1. A method for interventional treatment of a patient having a lymphatic system and heart with a myocardium comprising:
- providing a catheter having a tissue penetrating element disposed on its distal end and an inner lumen extending from its proximal end to its distal end;
providing a microdrug fluidic delivery system comprising a plurality of microspheres, said microsperes having an encapsulating layer and a therapeutic agent within the encapsulating layer, wherein said encapsulating layer is degradable when injected into the body tissue;
said microspeheres sized and dimensioned to prevent take up by the lymphatic system for a first time period;
said therapeutic agent comprising a genetic material;
injecting said microdrug interstitially to a depth within the myocardium to a first treatment site using the catheter;
treating the first treatment site for the first time period;
transporting the microdrug delivery system through a lymphatic system to a second treament site after the first time period;
treating a second treatment site within the patient with the microdrug delivery system.
3 Assignments
0 Petitions
Accused Products
Abstract
A method of treating the heart and other body tissues by injecting a compound comprised of microsphere encapsulated macromolecule therapeutic agents into the myocardium, such that the microsphere size inhibits capillary transport of the compound but may permit lymphatic transport of the compound, and the compound releases therapeutic agents upon degradation of the microsphere.
-
Citations
15 Claims
-
1. A method for interventional treatment of a patient having a lymphatic system and heart with a myocardium comprising:
-
providing a catheter having a tissue penetrating element disposed on its distal end and an inner lumen extending from its proximal end to its distal end;
providing a microdrug fluidic delivery system comprising a plurality of microspheres, said microsperes having an encapsulating layer and a therapeutic agent within the encapsulating layer, wherein said encapsulating layer is degradable when injected into the body tissue;
said microspeheres sized and dimensioned to prevent take up by the lymphatic system for a first time period;
said therapeutic agent comprising a genetic material;
injecting said microdrug interstitially to a depth within the myocardium to a first treatment site using the catheter;
treating the first treatment site for the first time period;
transporting the microdrug delivery system through a lymphatic system to a second treament site after the first time period;
treating a second treatment site within the patient with the microdrug delivery system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. A system for interventional treatment of a patient having a lymphatic system and a heart with a myocardium comprising:
-
a catheter having a tissue penetrating element disposed on its distal end and an inner lumen extending from its proximal end to its distal end, said tissue penetrating element adapted to penetrate the endocardium of a chamber of a heart to a depth withing the myocardium; and
a microdrug fluidic delivery system disposed within the catheter comprising a plurality of microspheres, said microsperes having an encapsulating layer and a therapeutic agent within the encapsulating layer, wherein said encapsulating layer is degradable when injected into the body tissue;
said therapeutic agent comprising a genetic material;
said microspeheres sized and dimensioned to prevent take up by the lymphatic system for a first time period. - View Dependent Claims (10, 11, 12, 13, 14, 15)
-
Specification