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Method of drug delivery to interstitial regions of the myocardium

  • US 20060020158A1
  • Filed: 09/06/2005
  • Published: 01/26/2006
  • Est. Priority Date: 03/13/1997
  • Status: Abandoned Application
First Claim
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1. A method for interventional treatment of a patient having a lymphatic system and heart with a myocardium comprising:

  • providing a catheter having a tissue penetrating element disposed on its distal end and an inner lumen extending from its proximal end to its distal end;

    providing a microdrug fluidic delivery system comprising a plurality of microspheres, said microsperes having an encapsulating layer and a therapeutic agent within the encapsulating layer, wherein said encapsulating layer is degradable when injected into the body tissue;

    said microspeheres sized and dimensioned to prevent take up by the lymphatic system for a first time period;

    said therapeutic agent comprising a genetic material;

    injecting said microdrug interstitially to a depth within the myocardium to a first treatment site using the catheter;

    treating the first treatment site for the first time period;

    transporting the microdrug delivery system through a lymphatic system to a second treament site after the first time period;

    treating a second treatment site within the patient with the microdrug delivery system.

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