Neurostimulation system with distributed stimulators

• US 20060020297A1
• Filed: 10/29/2004
• Published: 01/26/2006
• Est. Priority Date: 07/20/2004
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gerber, Martin T., Weimer, William D.
• Application Number:
  US10/977,336
• Publication Number:
  US 20060020297A1
• Time in Patent Office: Days
• US Class Current: 607/39
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula

Abstract

The disclosure is directed to a neurostimulation system and method that make use of remote, distributed stimulators implanted at selected positions within a patient. Each stimulator is capable of independently delivering neurostimulation energy to a patient. A master controller communicates with the stimulator by wireless telemetry, and controls and synchronizes the operation of the stimulators on a selective basis to deliver a desired mode of neurostimulation energy to the patient. The distributed stimulators function as remote “slave” stimulators that can be used to selectively stimulate various nerves. In this manner, the stimulators can be selectively activated and used in a coordinated manner to provide a multi-function stimulation generator or a multi-site stimulator.

Claims

1. A method for delivering neurostimulation therapy, the method comprising:

applying first neurostimulation therapy to a patient via a first set of one or more implanted stimulators; and

applying second neurostimulation therapy to the patient via a second set of one or more implanted stimulators,

wherein at least some of the stimulators in the first set are positioned at sites that are different from sites at which at least some of the stimulators in the second set are positioned.

2. The method of claim 1, further comprising applying the first and second neurostimulation therapies at different times.

3. The method of claim 1, further comprising applying the first neurostimulation therapy to support a first phase of physiological activity by the patient, and applying the second neurostimulation therapy to support a second phase of physiological activity.

4. The method of claim 1, wherein the first and second phases of physiological activity are first and second phases of sexual activity.

5. The method of claim 1, wherein the first phase includes sexual arousal and the second phase includes sexual orgasm.

6. The method of claim 1, wherein the first and second phases of physiological activity are first and second phases of urinary activity.

7. The method of claim 1, wherein the first phase includes urinary retention and the second phase includes urinary voiding.

8. The method of claim 1, further comprising sensing one or more physiological conditions within the patient, and adjusting at least one of the first neurostimulation therapy and the second neurostimulation therapy based on the sensed physiological conditions.

9. The method of claim 8, wherein sensing includes sensing the physiological conditions with an implanted sensor and transmitting a sensor signal representing the sensed physiological conditions by wireless communication to at least one of the stimulators.

10. The method of claim 9, further comprising adjusting at least one of the first and second neurostimulation therapies in response to the transmitted sensor signal.

11. The method of claim 9, further comprising deactivating application of the first neurostimulation therapy and activating application of the second neurostimulation therapy in response to the transmitted sensor signal.

12. The method of claim 8, further comprising sensing the one or more physiological conditions via one of a plurality of implanted sensors.

13. The method of claim 8, wherein the one or more sensed physiological conditions include at least one of penile pressure, penile electromyographic potential, penile blood flow, penile tumescence, and penile size.

14. The method of claim 8, wherein the one or more sensed physiological conditions include at least one of bladder flow, bladder electromyographic potential, bladder pressure, and urethral flow.

15. The method of claim 1, further comprising deactivating the first neurostimulation energy and activating the second neurostimulation for transition from a first phase of physiological activity to a second phase of physiological activity.

16. The method of claim 1, further comprising deactivating the first neurostimulation therapy and activating the second neurostimulation in response to a triggering event.

17. The method of claim 16, wherein the triggering event includes a user command, a change in a physiological parameter, or a timing event.

18. The method of claim 17, wherein the triggering event includes a combination of at least two of a user command, a change in a physiological parameter, or a timing event.

19. The method of claim 1, wherein the first neurostimulation therapy includes a set of neurostimulation parameters that are different from a set of neurostimulation parameters associated with the second neurostimulation therapy.

20. The method of claim 19, wherein the neurostimulation parameters include amplitude, pulse width, frequency, and duration.

21. The method of claim 1, wherein the stimulators are positioned for application of the first and second neurostimulation therapies to sacral nerves of the patient.

22. The method of claim 1, wherein the stimulators are positioned for application of the first and second neurostimulation therapies to at least one of the S2 and S3 sacral nerves of the patient.

23. The method of claim 1, wherein the stimulators are positioned for application of at least one of the first and second neurostimulation therapies to a pudendal nerve of the patient.

24. The method of claim 1, wherein the stimulators are positioned for application of one of the first and second neurostimulation therapies to the sacral nerves and the other of the first and second neurostimulation therapies to the pudendal nerve.

25. The method of claim 1, wherein the stimulators are positioned for application of the first neurostimulation therapy to the sacral nerves to support sexual arousal, and the second neurostimulation therapy to the pudendal nerve to support orgasm.

26. The method of claim 1, wherein the stimulators are positioned for application of the first neurostimulation therapy to the sacral nerves, and the second neurostimulation therapy to the pudendal nerve.

27. The method of claim 1, further comprising controlling the stimulators with one of the stimulators.

28. The method of claim 1, further comprising controlling the stimulators with an external controller.

29. The method of claim 1, wherein each of the stimulators includes a self-contained, self-powered stimulator module with at least two external electrodes.

30. The method of claim 29, wherein some of the stimulators further include a sensor to sense one or more physiological conditions within the patient.

31. A neurostimulation system comprising:

a first set of one or more implantable stimulators for delivery of a first neurostimulation therapy to a patient;

a second set of one or more implanted stimulators for delivery of a second neurostimulation therapy to the patient via a second set of one or more implanted stimulators; and

a controller to selectively activate the first set of stimulators to deliver the first neurostimulation therapy and the second set of stimulators to deliver the second neurostimulation therapy,

wherein at least some of the stimulators in the first set are positioned at sites that are different from sites at which at least some of the stimulators in the second set are positioned.

32. The system of claim 31, wherein the controller selectively activates the first and second sets of stimulators at different times.

33. The system of claim 31, wherein the controller activates the first set of stimulators to apply the first neurostimulation therapy to support a first phase of physiological activity by the patient, and activates the second set of stimulators to apply the second neurostimulation therapy to support a second phase of physiological activity.

34. The system of claim 31, wherein the first and second phases of physiological activity are first and second phases of sexual activity.

35. The system of claim 31, wherein the first phase includes sexual arousal and the second phase includes sexual orgasm.

36. The system of claim 31, wherein the first and second phases of physiological activity are first and second phases of urinary activity.

37. The system of claim 31, wherein the first phase includes urinary retention and the second phase includes urinary voiding.

38. The system of claim 31, further comprising one or more implantable sensors to sense one or more physiological conditions within the patient, wherein the controller adjusts at least one of the first neurostimulation therapy and the second neurostimulation therapy based on the sensed physiological conditions.

39. The system of claim 38, wherein each of the sensors includes a wireless transmitter to transmit a sensor signal representing the sensed physiological conditions to the controller.

40. The system of claim 39, wherein the controller adjusts at least one of the first and second neurostimulation therapies in response to the transmitted sensor signal.

41. The system of claim 39, wherein the controller deactivates the first set of stimulators to cease application of the first neurostimulation therapy and activates the second set of stimulators to apply the second neurostimulation therapy in response to the transmitted sensor signal.

42. The system of claim 38, wherein the one or more sensed physiological conditions include at least one of penile pressure, penile electromyographic potential, penile blood flow, penile tumescence, and penile size.

43. The system of claim 38, wherein the one or more sensed physiological conditions include at least one of bladder flow, bladder electromyographic potential, bladder pressure, and urethral flow.

44. The system of claim 31, wherein the controller deactivates the first set of stimulators to cease application of the first neurostimulation therapy and activates the second set of stimulators to apply the second neurostimulation therapy for transition from a first phase of physiological activity to a second phase of physiological activity.

45. The system of claim 31, wherein the controller deactivates the first set of stimulators to cease application of the first neurostimulation therapy and activates the second set of stimulators to apply the second neurostimulation therapy in response to a triggering event.

46. The system of claim 45, wherein the triggering event includes a user command, a change in a physiological parameter, or a timing event.

47. The system of claim 46, wherein the triggering event includes a combination of at least two of a user command, a change in a physiological parameter, or a timing event.

48. The system of claim 31, wherein the first neurostimulation therapy includes a set of neurostimulation parameters that are different from a set of neurostimulation parameters associated with the second neurostimulation therapy.

49. The system of claim 48, wherein the neurostimulation parameters includes amplitude, pulse width, frequency, and duration.

50. The system of claim 31, wherein the stimulators are positioned for application of the first and second neurostimulation therapies to sacral nerves of the patient.

51. The system of claim 31, wherein the stimulators are positioned for application of the first and second neurostimulation therapies to at least one of the S2 and S3 sacral nerves of the patient.

52. The system of claim 31, wherein the stimulators are positioned for application of at least one of the first and second neurostimulation therapies to a pudendal nerve of the patient.

53. The system of claim 31, wherein the stimulators are positioned for application of one of the first and second neurostimulation therapies to the sacral nerves and the other of the first and second neurostimulation therapies to the pudendal nerve.

54. The system of claim 31, wherein the stimulators are positioned for application of the first neurostimulation therapy to the sacral nerves, and the second neurostimulation therapy to the pudendal nerve.

55. The system of claim 31, wherein the controller resides within one of the stimulators, the respective stimulator include a wireless transmitter to transmit commands to the other stimulators.

56. The system of claim 31, wherein the controller includes an external controller carried by the patient.