Administration of CPAP treatment pressure in presence of apnea

• US 20060021618A1
• Filed: 09/28/2005
• Published: 02/02/2006
• Est. Priority Date: 11/07/1997
• Status: Active Grant

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Berthon-Jones, Michael, Farrugia, Steven Paul
• Granted Patent: US 8,511,307 B2
• Time in Patent Office: Days
• US Class Current: 128/204.180
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0875 Connecting tubes
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase

Abstract

CPAP treatment apparatus is disclosed having a controllable flow generator (34, 38, 40) operable to produce breathable gas at a treatment pressure elevated above atmosphere to a patient by a delivery tube (32) coupled to a mask (30) having connection with a patient'"'"'s airway. A sensor (44, 50, 56, 58) generates a signal representative of patient respiratory flow, that is provided to a controller (54, 62, 64). The controller (54, 62, 64) is operable to determine the occurrence of an apnea from a reduction in respiratory airflow below a threshold, and if an apnea has occurred, to determine the duration of the apnea and to cause the flow generator (34, 38) to increase the treatment pressure. In one preferred form the increase in pressure is zero if the treatment pressure before the apnea exceeds a pressure threshold. Below the pressure threshold the increase in pressure is an increasing function of the duration of the apnea multiplied by the difference between the pressure threshold and the current treatment pressure.

Claims

1-45. -45. (canceled)

46. A method for the administration of CPAP treatment pressure comprising the steps of:

supplying breathable gas to a patient'"'"'s airway at an initial treatment pressure, and repeatedly;

determining a measure of respiratory airflow;

determining the occurrence of an apnea from a reduction in said measure of respiratory airflow below a threshold;

determining the duration of said apnea; and

increasing the treatment pressure by an amount which is an increasing function of the duration of said apnea, and a decreasing function of the treatment pressure immediately before said apnea,

wherein no increase in pressure is made for apneas of less than approximately 10 seconds duration, or for apneas where the treatment pressure immediately prior to the apnea is more than approximately 10 cm H2O, but otherwise, the lower the treatment pressure immediately prior to the apnea, and the longer the apnea, the greater the increase in treatment pressure, up to a maximum of approximately 8 cm H2O per minute of apnea.

47. The method of claim 46, wherein said initial treatment pressure is approximately 4 cm H2O.

48. The method of claim 47, wherein said measure of respiratory airflow is approximately a two second moving average RMS airflow.

49. The method of claim 48, wherein said threshold is approximately twenty-five percent of the RMS airflow over the preceding five minutes.

50. The method of claim 46, wherein if there is no apnea, the treatment pressure is gradually reduced towards the initial minimum pressure with a time constant of approximately twenty minutes.

56. The method of claim 46, further comprising the steps of:

determining the occurrence of at least partial upper airway obstruction;

and if said obstruction is occurring, increasing said treatment pressure, and otherwise reducing said treatment pressure towards said initial treatment.

57. The method of claim 56, wherein said determination of upper airway obstruction is performed by detecting the presence of snoring.

58. The method of claim 57, wherein said determination of upper airway obstruction is performed by detecting the presence of characteristic changes in shape of an inspiratory flow versus time curve indicative of inspiratory airflow limitation.

59. The method of claim 46, further comprising the steps of:

measuring airway patency by

(i) modulating said treatment pressure by a pneumatic signal of known frequency and known amplitude,

(ii) measuring amplitude of induced airflow at said known frequency,

(iii) calculating conductance of airway, as being indicative of airway patency, by dividing said amplitude of induced airflow by said known amplitude, and

increasing said treatment pressure only if said conductance is greater than a threshold value.

63. The method of claim 46, wherein said increasing function of apnea duration is zero for zero apnea duration, and exponentially approaches an upper limit as apnea duration increases indefinitely.

51. CPAP treatment apparatus comprising:

a controllable flow generator operable to produce breathable gas at a pressure elevated above atmosphere;

a gas delivery tube coupled to the flow generator;

a patient mask coupled to the tube to receive said breathable gas from the generator and provide said gas, at a desired treatment pressure, to the patient'"'"'s airway;

a controller operable to receive input signals and to control operation of said flow generator and hence the treatment pressure; and

sensor means located at the flow generator, in the delivery tube or at the mask that generates a signal input to said controller from which patient respiratory airflow is determined;

and wherein said controller is operable to determine the occurrence of an apnea from a reduction in said respiratory airflow, determine the duration of said apnea, and cause said flow generator to increase CPAP treatment pressure by an increment that is an increasing function of said apnea duration and a decreasing function of the treatment pressure immediately prior to said apnea, said controller being operable such that no increase in pressure is made for apneas of less than approximately ten seconds duration, or for apneas where the treatment pressure immediately prior to the apnea is more than approximately 10 cm H2O, but otherwise, the lower the treatment pressure immediately prior to the apnea, and the longer the apnea, the greater the increase in treatment pressure, up to a maximum of approximately 8 cm H2O per minute of apnea.

52. The apparatus of claim 51, wherein said controller sets said initial treatment pressure to be approximately 4 cm H2O.

53. The apparatus of claim 52, wherein said controller measures said respiratory airflow as approximately a two second moving average RMS airflow.

54. The apparatus of claim 53, wherein said controller sets said threshold to be approximately twenty five percent of the RMS airflow over approximately the preceding five minutes.

55. The apparatus of claim 51, wherein said controller is further operable such that if there is an apnea, then the treatment pressure is gradually reduced towards the initial minimum pressure with a time constant of approximately twenty minutes.

60. The CPAP treatment apparatus of claim 51, wherein there is a further determination of the occurrence of at least partial upper airway obstruction, and further comprising means for detecting the presence of snoring, and if detected, said controller is further operable to increase said treatment pressure, and otherwise if not detected, operable to reduce said treatment pressure towards initial treatment pressure.

61. The CPAP treatment apparatus of claim 51, wherein there is a further determination of the occurrence of at least partial upper airway obstruction by the controller being further operable to detect the presence of characteristic changes in shape of an inspiratory flow versus time curve indicative of inspiratory airflow limitation.

62. The apparatus of claim 60, further for measuring airway patency, and wherein said flow generator modulates said treatment pressure by a pneumatic signal of known frequency and known amplitude, said sensor means measures amplitude of induced airway at said known frequency, and said controller calculates conductance of airway, as being indicative of airway patency, by dividing said amplitude of induced airflow by said known amplitude, and increases said treatment pressure only if said conductance is greater than a threshold value.