Hybrid device for cell therapies

• US 20060024276A1
• Filed: 07/20/2005
• Published: 02/02/2006
• Est. Priority Date: 07/29/2004
• Status: Active Grant

• Current Assignee: University of Miami
• Original Assignee: University of Miami
• Inventors: Ricordi, Camillo
• Granted Patent: US 7,910,359 B2
• Time in Patent Office: Days
• US Class Current: 424/93.700
• CPC Class Codes: A61M 2202/097 endothelial cells
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.

Claims

1. A device for receiving implanted biological material comprising:

a porous outer wall defining an inner space and a fluid manifold assembly for selectively infusing at least one of immunosuppressive and/or growth factor media to said space and a pump or a reservoir for such media, operatively coupled to said manifold assembly.

2. A device as in claim 1, further comprising a plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the wall.

3. A device as in claim 2, wherein said manifold assembly is formed separately from said plunger body, and said plunger body and said manifold assembly are selectively interchangeably placed within said space.

4. A device as in claim 3, wherein said manifold assembly includes a closure cap and at least one longitudinally disposed media distribution conduits for distributing media to said space.

5. A device as in claim 4, wherein there is a plurality of distribution conduits.

6. A device as in claim 4, wherein said at least one conduit is microperforated for distributing media along a length thereof.

7. A device as in claim 1, wherein the plunger body and the manifold assembly are complimentarily configured for simultaneous placement within the space.

8. A device as in claim 7, wherein the manifold assembly and the plunger body are selectively inserted into said space from opposite longitudinal ends of said device.

9. A device as in claim 7, wherein said manifold assembly includes a closure cap and at least one longitudinally disposed media distribution conduits for distributing media to said space.

10. A device as in claim 7, wherein there is a plurality of distribution conduits.

11. A device as in claim 10, wherein said at least one conduit is microperforated for distributing media along a length thereof.

12. A device as in claim 1, wherein the porous outer wall has first and second, generally parallel side walls.

13. A device as in claim 12, wherein said parallel side walls are curved.

14. A device as in claim 12, wherein the porous outer wall has second and third, convexly curved side walls.

15. A device as in claim 8, wherein the plunger body has built-in conduits to deliver a physiologic solution or the selected tissue/cell product at the time of removal of the plunger, either to facilitate plunger displacement or to simultaneously load the selected cell product.

16. A device as in claim 15, wherein the built-in conduits are selectively positioned parallel and between the drug delivery conduits of the manifold assembly.

17. A method for implanting biological material in a patient, comprising:

providing a device for receiving biological material, said device including a porous outer wall defining an inner space and a fluid manifold assembly for selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space and a pump or a reservoir for such media, operatively coupled to said manifold assembly;

implanting said device at a selected location within the patient;

allowing tissue ingrowth through said porous outer wall into said inner space;

disposing a biological material comprising a selected tissue/cell product within said inner space; and

selectively infusing at least one of immunosuppressive and/or growth factor media to said inner space.

18. A method as in claim 17, wherein said implanting comprises implanting said device in a location selected from the group consisting of intraomental, subcutaneous, and intraperitoneal.

19. A method as in claim 17, further comprising disposing a plunger body in said inner space and so as to define a peripheral gap between the plunger and the wall, whereupon said tissue ingrowth is into said peripheral gap.

20. A method as in claim 19, further comprising removing said plunger after said allowing tissue ingrowth, and before said disposing a biological material.

21. A method as in claim 17, wherein said disposing a biological material precedes said implanting.