Compressed composite delivery system for release-rate modulation of bioactives
First Claim
Patent Images
1. A delivery system comprising a central core, a first outer zone, and a second outer zone in which:
- the central core comprises one or more biologically active ingredients, the first outer zone partially surrounds the core, the second outer zone partially surrounds the core, at least one of the first outer zone and the second outer zone comprises one or more biologically active ingredients, which one or more biologically active ingredients are the same as or different than the one or more biologically active ingredients in the core, the first outer zone and the second outer zone are heterogeneous with respect to each other, the first outer zone and the second outer zone together form a continuous layer completely enclosing the core, the first outer zone comprises a barrier suitable for timed release of biologically active ingredients, the second outer zone comprises a barrier suitable for timed release of biologically active ingredients, and the core, the first outer zone, and the second outer zone together comprise a biologically effective dosage amount of each of the one or more biologically active ingredients.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention is a delivery system comprising a first outer zone which partially surrounds an inner core, a second outer zone which also partially surrounds the core, and the outer zones together form a continuous heterogeneous layer fully surrounding the core. The delivery system is particularly suitable for orally administered multiple drug delivery or multiple rate delivery of biologically active ingredients to the gastrointestinal environment of humans or other animals.
-
Citations
36 Claims
-
1. A delivery system comprising a central core, a first outer zone, and a second outer zone in which:
-
the central core comprises one or more biologically active ingredients, the first outer zone partially surrounds the core, the second outer zone partially surrounds the core, at least one of the first outer zone and the second outer zone comprises one or more biologically active ingredients, which one or more biologically active ingredients are the same as or different than the one or more biologically active ingredients in the core, the first outer zone and the second outer zone are heterogeneous with respect to each other, the first outer zone and the second outer zone together form a continuous layer completely enclosing the core, the first outer zone comprises a barrier suitable for timed release of biologically active ingredients, the second outer zone comprises a barrier suitable for timed release of biologically active ingredients, and the core, the first outer zone, and the second outer zone together comprise a biologically effective dosage amount of each of the one or more biologically active ingredients. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
-
17. A delivery system comprising a central core, a first outer zone, and a second outer zone;
-
in which;
the central core comprises one or more biologically active ingredients;
the first outer zone partially surrounds the core, the second outer zone partially surrounds the core, at least one of the first outer zone and the second outer zone comprises one or more biologically active ingredients, which one or more biologically active ingredients are the same as or different than the one or more biologically active ingredients in the core;
the first outer zone and the second outer zone are heterogeneous with respect to each other, the first outer zone and the second outer zone together form a continuous layer completely enclosing the core, the first outer zone comprises a barrier suitable for timed release of one or more biologically active ingredients;
the second outer zone comprises a barrier suitable for timed release of one or more biologically active ingredients;
either the barrier of the first outer zone or the barrier of the second outer zone, but not both, comprises a substantially non-erodable, swellable barrier that facilitates gastro-retentive properties of the delivery system; and
the core, the first outer zone, and the second outer zone together comprise a biologically effective dosage amount of each of the one or more biologically active ingredients;
- View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
-
29. A method for the controlled release of one or more biologically active ingredients, the method comprising administering a delivery system to an animal, the delivery system comprising a central core, a first outer zone, and a second outer zone,
in which: -
the central core comprises one or more biologically active ingredients, the first outer zone partially surrounds the core, the second outer zone partially surrounds the core, at least one of the first outer zone and the second outer zone comprises one or more biologically active ingredients, which one or more biologically active ingredients are the same as or different than the one or more biologically active ingredients in the core, the first outer zone and the second outer zone are heterogeneous with respect to each other, the first outer zone and the second outer zone together form a continuous layer completely enclosing the core, the first outer zone comprises a barrier suitable for timed release of biologically active ingredients, the second outer zone comprises a barrier suitable for timed release of biologically active ingredients, and the core, the first outer zone, and the second outer zone together comprise a biologically effective dosage amount of each of the one or more biologically active ingredients. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36)
-
Specification