Composite materials for controlled release of water soluble products
First Claim
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1. A controlled release composite comprising:
- a basic inorganic material;
a water-soluble compound adsorbed to said basic inorganic material; and
a bio-degradable polymer which yields acidic degradation products whereby acidic degradation products from said polymer facilitate dissolution of said basic inorganic material and release of said adsorbed compound.
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Abstract
Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materials are designed so as to provide controlled release of the water soluble molecule.
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Citations
80 Claims
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1. A controlled release composite comprising:
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a basic inorganic material;
a water-soluble compound adsorbed to said basic inorganic material; and
a bio-degradable polymer which yields acidic degradation products whereby acidic degradation products from said polymer facilitate dissolution of said basic inorganic material and release of said adsorbed compound. - View Dependent Claims (2, 4, 5, 6, 7, 8, 12, 13, 17, 19)
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3. canceled.
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9-11. -11. (canceled)
- 14. The controlled release composite of claim 14, wherein said amphoteric species serves as a diffusion barrier to the liberated compound.
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16. (canceled)
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20. A process for preparing a composite scaffolding comprising a water-soluble compound, comprising the steps of:
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(a) adsorbing a water-soluble compound onto a basic, inorganic material;
(b) combining the product in (a) with a solution of a biodegradable polymer which yields acidic degradation products to form a solid-in oil emulsion;
(c) precipitating the composite scaffolding product in (b); and
(d) isolating said composite scaffolding. - View Dependent Claims (18, 21, 23, 24, 25, 26, 27, 28, 29, 30, 32, 33, 34, 35, 36, 37, 38)
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22. (canceled)
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31. (canceled)
- 39. A method of controlled delivery of a therapeutic water-soluble compound to a subject, comprising administering to said subject a controlled release composite comprising a therapeutic water-soluble compound adsorbed onto a basic, inorganic material and a bio-degradable polymer which yields acidic degradation products, whereby degradation of said polymer yields acidic degradation products therefrom, which stimulates dissolution of the inorganic material and release of said therapeutic water-soluble compound over a period of time, thereby being a method of controlled delivery of a therapeutic water-soluble compound.
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43-45. -45. (canceled)
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51. (canceled)
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53-59. -59. (canceled)
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67-71. -71. (canceled)
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72. A method of tissue engineering comprising the step of contacting a cell with a composite scaffolding comprising a water-soluble tissue-promoting factor adsorbed onto a basic, inorganic material and a bio-degradable polymer which yields acidic degradation products, whereby degradation of said polymer yields acidic degradation products therefrom, which stimulates dissolution of said inorganic material and release of said water-soluble tissue-promoting factor, and whereby said cell responds to said tissue-promoting factor, promoting tissue formation, thereby providing a method of tissue engineering.
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75. (canceled)
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76. A method of stimulating or enhancing bone repair, or maintaining or increasing bone volume, bone quality, or bone strength in the body of a subject in need, comprising the steps of:
- contacting a cell in said subject with a composite controlled release system comprising a water-soluble factor adsorbed onto a basic, inorganic material and a bio-degradable polymer which yields acidic degradation products, whereby degradation of said polymer yields acidic degradation products therefrom, which stimulates dissolution of said inorganic material and release of said water-soluble factor, and whereby said cell responds to said factor, promoting bone repair, increased bone volume, bone quality, or bone strength, thereby providing a method of stimulating or enhancing bone repair, or maintaining or increasing bone volume, bone quality, or bone strength in the body of a subject in need.
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77-78. -78. (canceled)
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79. A method of nucleic acid delivery, comprising contacting a cell with a composite controlled release system comprising a nucleic acid adsorbed onto a basic, inorganic material and a bio-degradable polymer which yields acidic degradation products, whereby degradation of said polymer yields acidic degradation products therefrom, which stimulates dissolution of the inorganic material and release of said nucleic acid, thereby being a method of nucleic acid delivery.
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80-85. -85. (canceled)
Specification