Hydroxybenazamide compounds for treatment of cancer
First Claim
Patent Images
1. A method of inhibiting growth of a cancer cell comprising an intact raf signaling pathway comprising contacting said cell with an effective amount of a compound having the structure:
- or a prodrug or an analog thereof.
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides for the treatment of cancers, particularly neuroendocrine cancers, using the Raf-1 inducer ZM336372, or analogs thereof.
4 Citations
53 Claims
-
1. A method of inhibiting growth of a cancer cell comprising an intact raf signaling pathway comprising contacting said cell with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof. - View Dependent Claims (2, 3, 4, 11, 12, 13, 14, 15)
-
-
12. The method of claim 1, wherein an effective amount comprises about 200 mg to about 3 grams per day.
-
13. The method of claim 1, wherein an effective amount comprises about 0.0067 mg/kg to about 66.7 mg/kg per day.
-
14. The method of claim 1, further comprising contacting said cell with a second agent.
-
15. The method of claim 14, wherein said second agent is radiation, a chemotherapeutic, or a biological anti-cancer agent.
-
5-10. -10. (canceled)
-
16-18. -18. (canceled)
-
19. A method of treating a cancer in a subject, cells of said cancer comprising an intact raf signaling pathway, comprising contacting said subject with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
-
20-36. -36. (canceled)
-
37. A method of inhibiting growth of a cancer cell comprising an intact p21 signaling pathway comprising contacting said cell with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
-
38. A method of treating a cancer in a subject, cells of said cancer comprising an intact p21 signaling pathway, comprising contacting said subject with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
- 39. (canceled)
-
40. A method of treating a neuroendocrine cancer in a subject comprising contacting said subject with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
-
41. (canceled)
-
42. A method of treating a carcinoid cancer in a subject comprising contacting said subject with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
-
43-44. -44. (canceled)
-
45. A method of treating a glioma cancer in a subject comprising contacting said subject with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
-
47. A method of screening a candidate substance for activity against carcinoid cancer cells comprising:
-
(a) providing a cell having an intact raf signaling pathway;
(b) contacting said cell with candidate substance; and
(c) assessing the effect of said candidate substance on the raf signaling pathway, wherein an increase in raf pathway signaling activity, as compared to that observed in the absence of said candidate substance, indicates that said candidate substance is active against carcinoid cancer cells.
-
-
48-51. -51. (canceled)
-
52. A method of reducing chromogranin levels in neuroendocrine cancer cell comprising contacting said subject with an effective amount of a compound having the structure:
-
or a prodrug or an analog thereof.
-
-
53-56. -56. (canceled)
Specification