Novel human GABA receptor proteins and polynucleotides encoding the same

• US 20060025581A1
• Filed: 07/25/2005
• Published: 02/02/2006
• Est. Priority Date: 01/18/2000
• Status: Abandoned Application

• Current Assignee: Arthur T. Sands, Brian Mathur, Brian Zambrowicz, Glenn Friedrich, Turner C. Alexander Jr
• Original Assignee: Arthur T. Sands, Brian Mathur, Brian Zambrowicz, Glenn Friedrich, Turner C. Alexander Jr
• Inventors: Sands, Arthur T., Zambrowicz, Brian, Friedrich, Glenn, Mathur, Brian, Turner, C. Alexander Jr.
• Application Number:
  US11/188,353
• Publication Number:
  US 20060025581A1
• Time in Patent Office: Days
• US Class Current: 536/23.500
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748
• CPC Class Codes: C07K 14/70571 for neuromediators, e.g. serotonin receptor, dopamine receptor

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1-4. -4. (canceled)

5. A gene delivery system comprising:

an isolated nucleic molecule comprising at least 100 contiguous bases of a nucleic acid sequence selected from the group consisting of SEQ ID NOS;

1, 3, 5, 7, 9 or 11.

6. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:

2, 4, 6, 8, 10 or 12.

7. An antibody having immunospecificity for a polypeptide sequence selected from the group consisting of SEQ ID NOS:

2, 4, 6, 8, 10 or 12.