Coaxial catheter systems for transference of medium

• US 20060025752A1
• Filed: 07/28/2005
• Published: 02/02/2006
• Est. Priority Date: 07/28/2004
• Status: Active Grant

• Current Assignee: University of Virginia Patent Foundation (University of Virginia), Virginia Commonwealth University
• Original Assignee: University of Virginia Patent Foundation (University of Virginia)
• Inventors: Chen, Zhi-Jian, Gillies, George T., Broaddus, William C.
• Granted Patent: US 7,727,225 B2
• Time in Patent Office: Days
• US Class Current: 604/537
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: A61M 5/007 for contrast media

Abstract

A method, technique and system is disclosed for the delivery of therapeutic agents and/or into the bulk brain tissues and other parts, tissues and organs of the body, including vasculature. A novel form of coaxial catheter provides a means for implanting an outer tube into the brain, then inserting an inner tube into the outer tube and aligning them such that port holes on both of the tubes will overlap and permit a flux of the therapeutic agent to flow into the brain in such a way as to minimize the effects of trapped air, virtually eliminate backflow of the agent, and avoid the potential for additional damage to the brain since only one surgical placement of the outer tube is needed. Similarly, the method, technique system may be utilized to remove fluids or other medium from the brain, tissues, and organs to minimize the effects of escaped air or negative pressure.

Claims

1. A catheter device for transferring at least one medium with a subject, wherein said catheter having a distal end and a proximal end, said device comprising:

an outer tube having a distal end and a proximal end, and having a wall extending longitudinally there between;

an inner tube disposed within said outer tube, said inner tube having a distal end and a proximal end, and having a wall extending longitudinally there between defining a inner tube flow area for transference of the medium;

a longitudinal space between said outer tube and inner tube defining an inter-tube gap;

at least one outer tube aperture disposed on said outer tube wall;

at least one inner tube aperture disposed on said inner tube wall;

said inner tube being adapted to move longitudinally and/or circumferentially relative to said outer tube to provide for said at least one inner tube aperture to be in communication with said at least one outer tube aperture to allow transference of the medium between said inner tube and the subject; and

a sealing system disposed in said inter-tube gap to control the medium from traveling within said inter-tube gap.

2. The device of claim 1, wherein said seal system controls medium travel in said inter-tube gap in the direction of the catheter proximal end and the distal end.

3. The device of claim 1, wherein control of the medium travel by said seal system is reduction of travel.

4. The device of claim 3, further comprising a passage disposed on said catheter device extending from said catheter distal end toward catheter proximal end adapted to allow air to pass there through as a result of the relative movement of said inner tube and said outer tube.

5. The device of claim 3, wherein said seal system is selected from the group of structures consisting of flange, collet, gasket, engaged seal, joint, sleeve, grommet, bushing, annular rivet, snap closure, slip, pressure seal, elastic tension seal, pneumatic tension seal, tab, offset, protuberance, shelf, ledge, extension, lip, bulge, collet, flange, collar thimble, or ring, knob, friction-fit communication between the inner tube and outer tube, elastic conformance, threaded-fit, bayoneted-fit, locking mechanisms and circumferential sealing devices.

6. The device of claim 1, wherein control of the medium travel by said seal system is prevention of travel.

7. The device of claim 6, further comprising a passage disposed on said catheter device extending from said catheter distal end toward catheter proximal end adapted to allow air to pass there through as a result of the relative movement of said inner tube and said outer tube.

8. The device of claim 6, wherein said seal system is selected from the group of structures consisting of flange, collet, gasket, engaged seal, joint, sleeve, grommet, bushing, annular rivet, snap closure, slip, pressure seal, elastic tension seal, pneumatic tension seal, tab, offset, protuberance, shelf, ledge, extension, lip, bulge, collet, flange, collar, thimble, or ring, knob, friction-fit communication between the inner tube and outer tube, elastic conformance, threaded-fit, bayoneted-fit, locking mechanisms and circumferential sealing devices.

9. The device of claim 1, further comprising a passage disposed on said catheter device extending from said catheter distal end toward catheter proximal end adapted to allow air to pass there through as a result of the relative movement of said inner tube and said outer tube.

10. The device of claim 9, wherein said passage comprises a lumen.

11. The device of claim 9, wherein said passage comprises at least one of the following:

conduit, channel, passage, pipe, tunnel, tube or bounded tubular surface.

12. The device of claim 9, wherein said passage being adapted to allow flushing of a residual medium existing in said inner tube.

13. The device of claim 1, wherein said transference of the medium comprises delivering the medium from said inner tube to the subject.

14. The device of claim 13, wherein said delivered medium comprises at least one of chemotherapies, cell slurries, gene therapy vectors, growth factors, contrast agents, angiogenesis factors, radionuclide slurries, anti-infection agents, anti-tumor compounds, receptor-bound agents and/or other types of drugs, therapeutic and/or diagnostic or agents.

15. The device of claim 1, wherein said transference of the medium comprises withdrawing the medium from the subject to said inner tube.

16. The device of claim 15, wherein said withdrawn medium comprises at least one of edematous fluids, blood, cerebrospinal fluid, interstitial fluid, infected materials, neoplastic fluids and tissues and other such substances.

17. The device of claim 1, wherein said inner tube comprises a catheter.

18. The device of claim 1, wherein said inner tube comprises at least one of the following:

conduit, channel, passage, pipe, tunnel, or bounded tubular surface.

19. The device of claim 1, wherein said outer tube comprises a catheter.

20. The device of claim 1, wherein said outer tube comprises at least one of the following:

conduit, channel, passage, pipe, tunnel, or bounded tubular surface.

21. The device of claim 1, further comprising:

a flushing passage disposed on said catheter device extending from said catheter distal end toward said catheter proximal end adapted to allow flushing of a residual medium existing in said inner tube.

22. The device of claim 21, wherein said flushing passage is disposed inside said inner tube.

23. The device of claim 21, wherein said flushing passage is disposed on said inner tube.

24. The device of claim 1, further comprising:

a second passage disposed on said catheter device extending from said catheter distal end toward said catheter proximal end adapted to allow a transference of a second medium with the subject.

25. The device of claim 24, wherein said inner tube being adapted to move longitudinally and/or circumferentially relative to said outer tube to provide for said second passage to be in communication with said at least one outer tube aperture to allow transference of the second medium between said inner tube and the subject.

26. The device of claim 24, wherein the second medium comprises at least one of the following:

therapeutic agent, diagnostic agent, chemotherapies, cell slurries, gene therapy vectors, growth factors, contrast agents, angiogenesis agents, and other such substances.

27. The device of claim 24, wherein said second passage is disposed inside said inner tube.

28. The device of claim 24, wherein said second passage is disposed on said inner tube.

29. The device of claim 24, further comprising:

a third passage disposed on said catheter device extending from said catheter distal end toward catheter proximal end adapted to allow a transference of a third medium with the subject.

30. The device of claim 29, wherein said inner tube being adapted to move longitudinally and/or circumferentially relative to said outer tube to provide for said third passage to be in communication with said at least one outer tube aperture to allow transference of the third medium between said inner tube and the subject.

31. The device of claim 1, wherein the medium comprises at least one of the following:

diagnostic agent, therapeutic agent, chemotherapies, cell slurries, gene therapy vectors, growth factors, contrast agents, angiogenesis agents, and other such substances.

32. The device of claim 1, wherein said sealing system comprises at least one of gasket, o-ring, sleeve, grommet, bushing, annular rivet or other type of circumferential sealing device.

33. The device of claim 1, wherein said sealing system comprises at least one of tab, offset, protuberance, shelf, ledge, extension, lip, bulge, collet, flange, thimble, ring or knob.

34. The device of claim 1, wherein said seal system is selected from the group of structures consisting of snap closure, slip, pressure seal, elastic tension seal, collar, elastic conformance, threaded-fit, bayoneted-fit, locking mechanisms, engaged seal, and joint.

35. The device of claim 1, wherein said sealing system comprises friction-fit communication between said inner tube and outer tube.

36. The device of claim 1, wherein said sealing system prevents reflux of the medium.

37. The device of claim 1, wherein during said prevention of the medium traveling in said inter-gap, said sealing system is located longitudinally on the distal end side and proximal end side of said outer tube aperture and located longitudinally on the distal end side and proximal end side of said inner tube aperture.

38. The device of claim 1, wherein areas of the subject for use with said device comprises at least one of:

tissues, ducts, organs, and vasculature.

39. The device of claim 1, wherein areas of the subject for use with said device comprises brain tissues.

40. The device of claim 1, further comprising at least one microcoil in communication with said catheter device.

41. The device of claim 40, wherein said at least one microcoil is disposed on said catheter device.

42. A method for delivering at least one medium to a subject using a catheter device, wherein said method comprises:

inserting an outer tube into the subject, said outer tube having a distal end and a proximal end and comprising at least one aperture there between;

disposing an inner tube within said outer tube, said inner tube having a distal end and a proximal end and comprising at least one aperture there between;

providing the at least one medium into said inner tube; and

aligning said outer tube aperture and said inner tube aperture to allow the at least one medium to travel through said inner tube aperture and outer tube aperture to the subject while controlling the medium from traveling between the exterior of said inner tube and interior of said outer tube.

43. The method of claim 42, wherein said controlling is a prevention of travel.

44. The method of claim 43, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

45. The method of claim 42, wherein said controlling comprises preventing the medium from traveling in the direction of the catheter proximal end and the distal end.

46. The method of claim 42, wherein said controlling is a reduction of travel.

47. The method of claim 46, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

48. The method of claim 42, wherein said controlling comprises reducing the medium from traveling in the direction of the catheter proximal end and the distal end.

49. The method of claim 42, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

50. The method of claim 42, wherein the medium being delivered comprises at least one of chemotherapies, cell slurries, gene therapy vectors, growth factors, contrast agents, angiogenesis factors, radionuclide slurries, anti-infection agents, anti-tumor compounds, receptor-bound agents and/or other types of drugs, therapeutic and/or diagnostic or agents.

51. The method of claim 42, further comprising withdrawing a medium from the subject, said method comprising:

aligning said outer tube aperture and said inner tube aperture to allow the at least one medium to travel from the subject through said outer tube aperture and inner tube aperture to the inner tube while controlling the medium from traveling between the exterior of said inner tube and interior of said outer tube.

52. The method of claim 51, wherein said controlling is a prevention of travel.

53. The method of claim 52, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

54. The method of claim 51, wherein said controlling comprises preventing the medium from traveling in the direction of the catheter proximal end and the distal end.

55. The method of claim 51, wherein said controlling is a reduction of travel.

56. The method of claim 55, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

57. The method of claim 51, wherein said controlling comprises reducing the medium from traveling in the direction of the catheter proximal end and the distal end.

58. The method of claim 51, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

59. The method of claim 51, wherein the medium being withdrawn comprises at least one of edematous fluids, blood, cerebrospinal fluid, interstitial fluid, infected materials, neoplastic fluids and tissues, and other such substances.

60. The method of claim 42, wherein said catheter is positioned under non-invasive imaging guidance.

61. The method of claim 42, wherein said catheter is positioned near a targeted area of treatment using non-invasive imaging guidance.

62. A method for withdrawing at least one medium to a subject using a catheter device, wherein said method comprising:

inserting an outer tube into the subject, said outer tube having a distal end and a proximal end and comprising at least one aperture there between;

disposing an inner tube within said outer tube, said inner tube having a distal end and a proximal end and comprising at least one aperture there between; and

aligning said outer tube aperture and said inner tube aperture to allow the at least one medium to travel from the subject through said outer tube aperture and inner tube aperture to the inner tube while controlling the medium from traveling between the exterior of said inner tube and interior of said outer tube.

63. The method of claim 62, wherein said controlling is a prevention of travel.

64. The method of claim 63, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

65. The method of claim 62, wherein said controlling comprises preventing the medium from traveling in the direction of the catheter proximal end and the distal end.

66. The method of claim 62, wherein said controlling is a reduction of travel.

67. The method of claim 66, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

68. The method of claim 62, wherein said controlling comprises reducing the medium from traveling in the direction of the catheter proximal end and the distal end.

69. The method of claim 62, further comprising allowing trapped air inside said outer tube in vicinity of the distal end of said outer tube to escape when said inner tube is disposed into said outer tube.

70. The method of claim 62, wherein the medium being withdrawn comprises at least one of edematous fluids, blood, cerebrospinal fluid, interstitial fluid, infected materials, neoplastic fluids and tissues, and other such substances.