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Transgenic non-human animals for producing heterologous and chimeric antibodies

  • US 20060026703A1
  • Filed: 12/10/2004
  • Published: 02/02/2006
  • Est. Priority Date: 08/29/1990
  • Status: Abandoned Application
First Claim
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1. A transgenic mouse comprising an unrearranged human heavy chain immunoglobulin variable region, wherein the variable region comprises multiple human VH gene segments, multiple human D gene segments, multiple human JH gene segments, and wherein B lymphocytes of the transgenic mouse express an antibody comprising a human immunoglobulin heavy chain variable region.

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