Sensor films and systems and methods of detection using sensor films

• US 20060029516A1
• Filed: 08/09/2004
• Published: 02/09/2006
• Est. Priority Date: 08/09/2004
• Status: Abandoned Application

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Potyrailo, Radislav Alexandrovich
• Application Number:
  US10/913,909
• Publication Number:
  US 20060029516A1
• Time in Patent Office: Days
• US Class Current: 422/56
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Abstract

A sensor film as well as a method and sensor array for detecting at least one analyte is described. The method of detecting at least one analyte includes providing at least one sensor, disposing at least one sensor film on the sensor, placing the sensor disposed with the sensor film in an environment that may contain at least one analyte, and relating at least one quantitative response to the concentration of the analyte.

Claims

1. A sensor film comprising;

at least one biopolymer protein material;

wherein the sensor film has a thickness greater than one biopolymer protein molecule; and

wherein the sensor film provides at least one quantitative response in relation to the concentration of at least one analyte.

2. The sensor film of claim 1, further comprising at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof.

3. The sensor film of claim 1, further comprising at least one reagent.

4. The sensor film of claim 1, wherein the at least one biopolymer protein material comprises a class of alcohol soluble prolamines.

5. The sensor film of claim 4, wherein the class of alcohol soluble prolamines comprises a zein group.

6. The sensor film of claim 1, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response, a viscoelastic response, a mass response, an optical response, and combinations thereof.

7. The sensor film of claim 1, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

8. The sensor film of claim 1, wherein the sensor film is configured to protect a surface of a sensor.

9. A sensor film comprising;

at least one biopolymer protein material;

at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof; and

at least one reagent;

wherein the sensor film has a thickness greater than one biopolymer protein molecule; and

wherein the sensor film provides at least one quantitative response in relation to the concentration of at least one analyte.

10. The sensor film of claim 9, wherein the at least one biopolymer protein material comprises a class of alcohol soluble prolamines.

11. The sensor film of claim 10, wherein the class of alcohol soluble prolamines comprises a zein group.

12. The sensor film of claim 9, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response, a viscoelastic response, a mass response, an optical response, and combinations thereof.

13. The sensor film of claim 9, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

14. The sensor film of claim 9, wherein the sensor film is configured to protect a surface of a sensor.

15. A method of detecting at least one analyte, the method comprising:

i) providing at least one sensor;

ii) disposing at least one sensor film on the at least one sensor, wherein the at least one sensor film comprises;

at least one biopolymer protein material, wherein a thickness of the at least one sensor film is greater than one biopolymer protein molecule and wherein the at least one sensor film provides at least one quantitative response in relation to the concentration of at least one analyte;

iii) placing the at least one sensor disposed with the at least one sensor film in an environment containing the at least one analyte; and

iv) relating the at least one quantitative response to the concentration of the at least one analyte.

16. The method of claim 15, wherein the at least one sensor film further comprises at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof.

17. The method of claim 15, wherein the at least one sensor film further comprises at least one reagent.

18. The method of claim 15, wherein the at least one biopolymer protein material comprises a class of alcohol soluble prolamines.

19. The method of claim 18, wherein the class of alcohol soluble prolamines comprises a zein group.

20. The method of claim 15, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response a viscoelastic response, a mass response, an optical response, and combinations thereof.

21. The method of claim 15, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

22. The method of claim 15, wherein the disposing of the at least one sensor film on the at least one sensor comprises disposing a plurality of the sensor films on the at least one sensor.

23. The method of claim 15, wherein the at least one sensor film further protects a surface of the at least one sensor.

24. The method of claim 15, wherein the at least one sensor comprises a plurality of sensors.

25. The method of claim 15, wherein the at least one analyte comprises a plurality of analytes.

26. The method of claim 15, further comprising monitoring the at least one analyte.

27. The method of claim 15 wherein the disposing is selected from a group consisting of ink-jet printing, spray coating, screen-printing, array microspotting, dip coating, solvent casting, draw coating and combinations thereof.

28. A method of detecting at least one analyte, the method comprising:

i) providing at least one sensor;

ii) disposing at least one sensor film on the at least one sensor, wherein the at least one sensor film provides at least one quantitative response in relation to the concentration of at least one analyte and wherein the at least one sensor film comprises;

at least one biopolymer protein material comprising a class of alcohol soluble prolamines, wherein a thickness of the at least one sensor film is greater than one molecule of the at least one biopolymer protein material; and

at least one reagent;

iii) placing the at least one sensor disposed with the at least one sensor film in an environment containing the at least one analyte; and

iv) relating the at least one quantitative response to the concentration of the at least one analyte.

29. The method of claim 28, wherein the at least one sensor film further comprises at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof.

30. The method of claim 28, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response a viscoelastic response, a mass response, an optical response, and combinations thereof.

31. The method of claim 28, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

32. The method of claim 28, wherein the disposing of the at least one sensor film on the at least one sensor comprises disposing a plurality of the sensor films on the at least one sensor.

33. The method of claim 28, wherein the at least one sensor film further protects a surface of the at least one sensor.

34. The method of claim 28, further comprising monitoring the at least one analyte.

35. The method of claim 28, wherein the disposing is selected from a group consisting of ink-jet printing, spray coating, screen-printing, array microspotting, dip coating, solvent casting, draw coating, and combinations thereof.

36. A sensor array configured for determining the presence of at least one analyte, the sensor array comprising:

at least one sensor; and

at least one sensor film disposed on the at least one sensor, wherein the at least one sensor film comprises;

at least one biopolymer protein material, wherein a thickness of the at least one sensor film is greater than one biopolymer protein molecule, and wherein the at least one sensor film provides at least one quantitative response in relation to the concentration of at least one analyte.

37. The sensor array of claim 36, wherein the at least one sensor film further comprises at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof.

38. The sensor array of claim 36, wherein the at least one sensor film further comprises at least one reagent.

39. The sensor array of claim 36, wherein the at least one biopolymer protein material comprises a class of alcohol soluble prolamines.

41. The sensor array of claim 36, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response, a viscoelastic response, a mass response, an optical response, and combinations thereof.

42. The sensor array of claim 36, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

43. The sensor array of claim 36, wherein the disposing the at least one sensor film on the at least one sensor comprises disposing a plurality of the sensor films on the at least one sensor.

44. The sensor array of claim 36, wherein the at least one sensor comprises a plurality of sensors.

45. The sensor array of claim 36, wherein the at least one analyte comprises a plurality of analytes.

46. The sensor array of claim 36, wherein the at least one sensor film further protects a surface of the at least one sensor.

40. The sensor array of claim 40, wherein the class of alcohol soluble prolamines comprises a zein group.

47. A method of making a sensor film comprising at least one biopolymer protein material, wherein a thickness of the sensor film is greater than one biopolymer protein molecule, and wherein the sensor film provides at least one quantitative response in relation to the concentration of at least one analyte, the method comprising:

i) providing at least one biopolymer protein material in a solvent;

ii) depositing the at least one biopolymer protein material onto a substrate; and

iii) removing the solvent.

48. The method of claim 47, wherein the disposing is selected from a group consisting of ink-jet printing, spray coating, screen-printing, array microspotting, dip coating, solvent casting, draw coating, and combinations thereof.

49. The method of claim 47, wherein the sensor film further comprises at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof.

50. The method of claim 47, wherein the sensor film further comprises at least one reagent.

51. The method of claim 47, wherein the at least one biopolymer protein material comprises a class of alcohol soluble prolamines.

52. The method of claim 51, wherein the class of alcohol soluble prolamines comprises a zein group.

53. The method of claim 47, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response, a viscoelastic response, a mass response, and combinations thereof.

54. The method of claim 47, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

55. The method of claim 47, wherein the sensor film is configured to protect a surface of the at least one sensor.

56. The method of claim 47, wherein the providing at least one biopolymer protein material in a solvent comprises dissolving the at least one biopolymer protein material in the solvent.

57. A method of making a sensor film comprising at least one biopolymer protein material, wherein a thickness of the sensor film is greater than one biopolymer protein molecule, and wherein the sensor film provides at least one quantitative response in relation to the concentration of at least one analyte, the method comprising:

i) providing at least one biopolymer protein material in a solvent; and

ii) depositing the at least one biopolymer protein material onto a substrate.

58. The method of claim 57, wherein the film further comprises at least one additive selected from a group consisting of a chemical reagent, a plasticizer, a polarity modifier, an acidity modifier, and combinations thereof.

59. The method of claim 57, wherein the film further comprises at least one reagent.

60. The method of claim 57, wherein the at least one biopolymer protein material comprises a class of alcohol soluble prolamines.

61. The method of claim 60, wherein the class of alcohol soluble prolamines comprises a zein group.

62. The method of claim 57, wherein the at least one quantitative response is selected from a group consisting of a dielectric response, a thickness response, a viscoelastic response, a mass response, and combinations thereof.

63. The method of claim 57, wherein the at least one quantitative response is selected from a group consisting of a chemical response, a physical response, and combinations thereof.

64. The method of claim 57, wherein the sensor film is configured to protect a surface of the at least one sensor.

65. The method of claim 57, wherein providing at least one biopolymer protein material in a solvent comprises dissolving the at least one biopolymer protein material in the solvent.