Medical devices with surface modification for regulating cell growth on or near the surface
First Claim
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1. A medical device for treating proliferative disorders in a mammal, comprising:
- a structural member;
a high oxidation state metal-containing compound on or near the surface of the structural member wherein the metal-containing compound comprises a metal selected from the group consisting of chromium (IV), chromium (V), chromium (VI), manganese (V), manganese (VI), manganese (VII), cobalt (III), nickel (III) and combinations thereof; and
a polymeric layer disposed over at least part of the structural member and the metal-containing compound, wherein the polymeric layer regulates the release rate of the metal-containing compound from the medical device upon implantation of the medical device in the mammal.
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Abstract
High oxidation state metal-containing compounds are formed on or applied to the surfaces of medical devices. These compounds can cause cytostatic, cytotoxic, and anti-proliferative effects to the cells on or near the implanted medical devices and thus reduce or eliminate undesirable cell growth or accumulation on the medical devices.
33 Citations
12 Claims
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1. A medical device for treating proliferative disorders in a mammal, comprising:
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a structural member;
a high oxidation state metal-containing compound on or near the surface of the structural member wherein the metal-containing compound comprises a metal selected from the group consisting of chromium (IV), chromium (V), chromium (VI), manganese (V), manganese (VI), manganese (VII), cobalt (III), nickel (III) and combinations thereof; and
a polymeric layer disposed over at least part of the structural member and the metal-containing compound, wherein the polymeric layer regulates the release rate of the metal-containing compound from the medical device upon implantation of the medical device in the mammal. - View Dependent Claims (2, 3, 4, 5)
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6. A method of treating a proliferative disorder in a mammal, comprising:
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implanting into the mammal a medical device at or near the site of the proliferative disorder, wherein the medical device comprises a structural member and a high oxidation state metal-containing compound on or near the surface of the structural member, and wherein the metal containing compound comprises a metal selected from the group consisting of chromium (IV), chromium (V), chromium (VI), manganese (V), manganese (VI), manganese (VII), cobalt (III), nickel (III) and combinations thereof; and
releasing in the mammal a therapeutically effective amount of the metal-containing compound from the medical device, wherein the metal-containing compound regulates cell growth. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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Specification