Method for coating substrate with antimicrobial agent and product formed thereby

• US 20060029675A1
• Filed: 07/26/2005
• Published: 02/09/2006
• Est. Priority Date: 07/26/2004
• Status: Abandoned Application

• Current Assignee: KCI Licensing Incorporated (3M Company)
• Original Assignee: KCI Licensing Incorporated (3M Company)
• Inventors: Ginther, Devin C.
• Application Number:
  US11/189,195
• Publication Number:
  US 20060029675A1
• Time in Patent Office: Days
• US Class Current: 424/486
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 9/122 Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61L 15/425 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61M 1/915 Constructional details of the pressure distribution manifold
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: F02B 1/12 with compression ignition with fuel-air charge ignited by compression ignition of an additional fuel F02B7/00
• CPC Class Codes: F02B 2075/125 Direct injection in the combustion chamber for spark ignition engines, i.e. not in pre-combustion chamber
• CPC Class Codes: F02D 13/0219 by shifting the phase, i.e. the opening periods of the valves are constant
• CPC Class Codes: F02D 13/0249 changing the valve timing only
• CPC Class Codes: F02D 13/0265 Negative valve overlap for temporarily storing residual gas in the cylinder
• CPC Class Codes: F02D 13/0273 Multiple actuations of a valve within an engine cycle
• CPC Class Codes: F02M 26/01 Internal exhaust gas recirculation, i.e. wherein the residual exhaust gases are trapped in the cylinder or pushed back from the intake or the exhaust manifold into the combustion chamber without the use of additional passages
• CPC Class Codes: Y02T 10/12 Improving ICE efficiencies

Abstract

A method for uniformly coating a foam or dressing with antimicrobial polymer incorporating agents, such as silver, and a foam or dressing formed by this process. Such foam or dressing is particularly useful in combination with negative pressure wound therapy.

Claims

1. A method for coating a foam for placement on a wound site, the method comprising the steps of:

combining a hydrophilic gel with silver to create a coating solution;

agitating the coating solution in a closed environment;

placing the foam in the closed environment;

saturating the foam with the coating solution;

removing excess solution from the saturated foam; and

drying the saturated foam.

2. The method of claim 1, wherein the foam comprises polyurethane.

3. The method of claim 1, wherein the coating solution comprises a silver hydrogel polymer.

4. The method of claim 3, wherein the coating contains PVP.

5. The method of claim 3, wherein the coating contains Chitosan.

6. The method of claim 3, wherein the coating contains silver sodium aluminosilicate.

7. The method of claim 1, further comprising the step of placing the solution in a holding tank after the step of combining the hydrophilic gel.

8. The method of claim 1, wherein the environment is a dark environment to prevent the foam from changing color.

9. The method of claim 1, wherein the foam comprises reticulated polyurethane die cut.

10. The method of claim 1, wherein the step of saturating the foam with the solution is accomplished through soaking the foam in the solution.

11. The method of claim 1, wherein the step of saturating the foam with the solution is accomplished through squeezing the foam in the solution to allow the foam to absorb the solution.

12. The method of claim 1, further comprising the step of weighing the saturated foam after the step of saturating the foam.

13. The method of claim 12, further comprising the step of weighing the foam a second time after the step of drying the foam.

14. The method of claim 1, wherein the step of drying the saturated foam comprises placing the foam in a convectional forced-air oven set to a predetermined temperature for a predetermined amount of time.

15. The method of claim 1, further comprising packaging the foam in a moisture vapor transmission rate pouch to limit exposure of the foam to light and to humidity.

16. The method of claim 1, further comprising:

placing the foam on a wound site;

covering the wound site with a drape;

connecting a vacuum hose at one end to the foam through the drape and at the other end to a vacuum;

applying negative pressure to the wound site to pull pathogens and other harmful material through the foam to kill the pathogens and harmful material.

17. A method for treating a wound, comprising the steps of:

combining a hydrophilic gel with silver to create a coating solution;

agitating the coating solution in a holding tank;

placing the foam in the holding tank;

saturating the foam with the coating solution by soaking the foam in the coating solution for a predetermined amount of time;

removing excess solution from the foam by rolling the saturated foam through a roller;

drying the foam in a convection oven at a temperature of about 90°

C. for at least about 6 minutes to completely dry the foam;

applying the foam to a wound surface;

connecting a vacuum to the foam;

draping the wound surface; and

applying negative pressure to the wound via the vacuum, wherein harmful materials from the wound are neutralized via the coating on the foam.

18. The method of claim 17, wherein the coating solution comprising a debriding agent.

19. The method of claim 17, wherein the coating comprises anesthetizing agents.

20. The method of claim 17, wherein the coating comprises a growth factor.