Label-free high-throughput optical technique for detecting biomolecular interactions
First Claim
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1. A biosensor comprising:
- (a) a two-dimensional grating comprised of a material having a high refractive index;
(b) a substrate layer that supports the two-dimensional grating; and
(c) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;
wherein, when the biosensor is illuminated a resonant grating effect is produced on the reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect.
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
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Citations
2 Claims
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1. A biosensor comprising:
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(a) a two-dimensional grating comprised of a material having a high refractive index;
(b) a substrate layer that supports the two-dimensional grating; and
(c) one or more specific binding substances immobilized on the surface of the two-dimensional grating opposite of the substrate layer;
wherein, when the biosensor is illuminated a resonant grating effect is produced on the reflected radiation spectrum, and wherein the depth and period of the two-dimensional grating are less than the wavelength of the resonant grating effect.
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2-104. -104. (canceled)
Specification