Method and apparatus for selective drug infusion via an intra-aortic flow diverter delivery catheter
First Claim
Patent Images
1. A local renal infusion system for treating a renal system in a patient from a location within the abdominal aorta associated with abdominal aortic blood flow into first and second renal arteries via respective first and second renal ostia having unique relative locations along the abdominal aorta wall, comprising:
- a local injection assembly;
a flow isolation assembly with a tubular wall having a longitudinal axis between a first end and a second end;
wherein the flow isolation assembly is adapted to be delivered to the location in a first condition with the tubular wall in a first configuration with a first diameter transverse to the longitudinal axis, and such that the first end is located upstream of the renal ostia and the second end is located downstream of the first end;
wherein the flow isolation assembly at the location is adjustable from the first condition to a second condition with the tubular wall in a second configuration;
wherein the tubular wall in the second configuration comprises a second diameter that is greater than the first diameter and that is substantially constant between the first and second ends such that a first region of abdominal aortic flow within an exterior flow path between the wall and the abdominal aortic wall is substantially isolated from a second region of abdominal aortic flow located within an interior flow path within the tubular wall, and further such that the first and second regions of abdominal aortic blood flow are not substantially diverted by the tubular shaped wall; and
wherein the local injection assembly is adapted to be fluidly coupled to a source of fluid agent located externally of the patient and to inject a volume of fluid agent from the source and into the first region between the abdominal aortic wall and the tubular wall in the second configuration at the location.
3 Assignments
0 Petitions
Accused Products
Abstract
A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
-
Citations
69 Claims
-
1. A local renal infusion system for treating a renal system in a patient from a location within the abdominal aorta associated with abdominal aortic blood flow into first and second renal arteries via respective first and second renal ostia having unique relative locations along the abdominal aorta wall, comprising:
-
a local injection assembly;
a flow isolation assembly with a tubular wall having a longitudinal axis between a first end and a second end;
wherein the flow isolation assembly is adapted to be delivered to the location in a first condition with the tubular wall in a first configuration with a first diameter transverse to the longitudinal axis, and such that the first end is located upstream of the renal ostia and the second end is located downstream of the first end;
wherein the flow isolation assembly at the location is adjustable from the first condition to a second condition with the tubular wall in a second configuration;
wherein the tubular wall in the second configuration comprises a second diameter that is greater than the first diameter and that is substantially constant between the first and second ends such that a first region of abdominal aortic flow within an exterior flow path between the wall and the abdominal aortic wall is substantially isolated from a second region of abdominal aortic flow located within an interior flow path within the tubular wall, and further such that the first and second regions of abdominal aortic blood flow are not substantially diverted by the tubular shaped wall; and
wherein the local injection assembly is adapted to be fluidly coupled to a source of fluid agent located externally of the patient and to inject a volume of fluid agent from the source and into the first region between the abdominal aortic wall and the tubular wall in the second configuration at the location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
-
-
68. A proximal coupler assembly for concurrent use with a bilateral local renal delivery device and percutaneous translumenal interventional device, wherein the bilateral local renal delivery device comprises an elongate body with a proximal end portion and a distal end portion and a local injection assembly located along the distal end portion, the assembly comprising:
-
a housing with a distal end and a proximal end;
wherein the distal end comprises a distal coupler that is adapted to be coupled to an introducer sheath that provides percutaneous translumenal access into a vasculature of a patient that leads to a location within an abdominal aorta associated with renal artery ostia;
wherein the proximal end comprises an adjustable hemostatic coupler;
wherein the adjustable hemostatic coupler is adapted to simultaneously receive the bilateral local renal delivery device and the percutaneous translumenal device into the housing and is substantially aligned along a longitudinal axis with the distal end of the housing;
means for securing the proximal end portion of the bilateral local renal delivery device off-axis relative to the longitudinal axis so as to reduce interference between the percutaneous translumenal interventional device and the bilateral local renal delivery device when the percutaneous translumenal interventional device is manipulated within the hemostatic valve. - View Dependent Claims (69)
-
Specification