Osteoimplant and method of making same
First Claim
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1. An osteoimplant which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape.
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Abstract
An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
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Citations
50 Claims
- 1. An osteoimplant which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape.
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35. A method of making an osteoimplant which comprises:
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a. providing a quantity of elongate bone particles;
b. mixing the elongate bone particles with an aqueous wetting agent to provide a fluid composition containing from about 5 to about 40 volume percent swollen, hydrated elongate bone particles;
c. introducing the fluid composition into a mold; and
,d. removing aqueous wetting agent thereby providing a coherent aggregate of elongate bone particles possessing the dimensions and shape of the osteoimplant. - View Dependent Claims (36, 37, 38)
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39. A method of making a plug for insertion in a cavity of an implant or bone defect site which comprises:
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a) providing a coherent aggregate of elongate bone particles;
b) lyophilizing the coherent aggregate of elongate bone particles; and
,c) forming the coherent aggregate of elongate bone particles into the plug before or after carrying out step (b).
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40. A method of making a plug for insertion in a cavity of an implant or bone defect site which comprises:
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a) providing a coherent aggregate of elongate bone particles;
b) subjecting the coherent aggregate of elongate bone particles to a compressive force; and
,c) forming the compressed coherent aggregate of elongate bone particles into the plug before or after carrying out step (b). - View Dependent Claims (41, 42, 43)
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44. A method of making a plug for insertion in a cavity of an implant or bone defect site which comprises:
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a) providing a coherent aggregate of elongate bone particles at least some of which possess surface-exposed collagen;
b) crosslinking elongate bone particles in the coherent aggregate through their mutually-contacting surface-exposed collagen; and
,c) shaping the crosslinked coherent aggregate of elongate bone particles into the plug before or after carrying out step (b).
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45. A method of treating a bone defect in which the bone defect site possesses at least one cavity which comprises inserting a plug in the cavity, the plug comprising a coherent aggregate of elongate bone particles sized and shaped to substantially fill said cavity.
Specification