Targeted therapeutic delivery of vitamin D compounds

• US 20060034851A1
• Filed: 08/25/2005
• Published: 02/16/2006
• Est. Priority Date: 02/13/1997
• Status: Abandoned Application

• Current Assignee: Genzyme Corporation (Sanofi )
• Original Assignee: Genzyme Corporation (Sanofi )
• Inventors: Mazess, Richard B., Bishop, Charles W.
• Application Number:
  US11/211,965
• Publication Number:
  US 20060034851A1
• Time in Patent Office: Days
• US Class Current: 424/155.100
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 47/548 Phosphates or phosphonates, e.g. bone-seeking phospholipids A61K47/544
• CPC Class Codes: A61K 47/551 one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
• CPC Class Codes: A61K 47/554 the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
• CPC Class Codes: A61K 47/6898 using avidin- or biotin-conjugated antibodies
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07K 16/30 from tumour cells

Abstract

The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.

Claims

1-23. -23. (canceled)

27. A method of treating bone diseases in a human subject, comprising administering to the subject an effective amount of a vitamin D conjugate, the conjugate comprising a vitamin D moiety and a bone-seeking molecule moiety.

28. A method as set forth in claim 27, wherein the bone-seeking molecule is a peptide having an affinity for bone.

29. A method as set forth in claim 28, wherein the peptide is a small acidic peptide.

30. A method as set forth in claim 29;

wherein the peptide is (Asp)₆ or (Glu)₆.

31. A method as set forth in claim 28, wherein the peptide is associated with osteonection, bone sialoprotein or osteopontin.

34-57. -57. (canceled)