Prevention and treatment of amyloidogenic disease

• US 20060034858A1
• Filed: 10/07/2005
• Published: 02/16/2006
• Est. Priority Date: 12/02/1997
• Status: Abandoned Application

• Current Assignee: Janssen Alzheimer Immunotherapy (Johnson & Johnson), Elan Pharmaceuticals Incorporated (Perrigo Company PLC)
• Original Assignee: Neuralab Ltd. (Perrigo Company PLC)
• Inventors: Schenk, Dale B.
• Application Number:
  US11/245,524
• Publication Number:
  US 20060034858A1
• Time in Patent Office: Days
• US Class Current: 424/185.100
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/53 DNA (RNA) vaccination
• CPC Class Codes: A61K 2039/55505 Inorganic adjuvants
• CPC Class Codes: A61K 2039/55555 Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
• CPC Class Codes: A61K 2039/55566 Emulsions, e.g. Freund's adjuvant, MF59
• CPC Class Codes: A61K 2039/55572 Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
• CPC Class Codes: A61K 2039/55577 Saponins; Quil A; QS21; ISCOMS
• CPC Class Codes: A61K 2039/6037 Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
• CPC Class Codes: A61K 2039/605 MHC molecules or ligands thereof
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/739 Lipopolysaccharides
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61K 38/193 Colony stimulating factors [CSF]
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61K 39/0007 Nervous system antigens; Prions
• CPC Class Codes: A61K 47/646 the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/2009 Inorganic compounds
• CPC Class Codes: A61K 9/2031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
• CPC Class Codes: A61K 9/2054 : Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/4866 : Organic macromolecular compounds
• CPC Class Codes: A61K 9/7023 : Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61P 25/00 : Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 : for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 37/00 : Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/4711 : Alzheimer's disease; Amyloid plaque core protein
• CPC Class Codes: C07K 16/18 : against material from animals or humans
• CPC Class Codes: C07K 2317/24 : containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
• CPC Class Codes: C07K 2317/567 : Framework region [FR]
• CPC Class Codes: C07K 2319/00 : Fusion polypeptide

Abstract

The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.

Claims

1. A pharmaceutical composition comprising Aβ

or an immunogenic fragment thereof presented by a virus or bacteria as part of an immunogenic composition effective to induce an immunogenic response comprising antibodies against Aβ

in a patient.

2. The pharmaceutical composition of claim 1, wherein Aβ

is Aβ

43, Aβ

42, Aβ

41, Aβ

40, or Aβ

39.

3. The pharmaceutical composition of claim 1, wherein the immunogenic Aβ

fragment is Aβ

1-5.

4. The pharmaceutical composition of claim 1, wherein the immunogenic Aβ

fragment is Aβ

1-6.

5. The pharmaceutical composition of claim 1, wherein the Aβ

or immunogenic fragment thereof is presented by a virus.

6. The pharmaceutical composition of claim 5, wherein the Aβ

or immunogenic fragment thereof is expressed as a fusion protein with an outer surface protein of the virus so that the Aβ

or immunogenic fragment thereof is displayed.

7. The pharmaceutical composition of claim 5, wherein the Aβ

or immunogenic fragment thereof is chemically cross-linked with an outer surface protein of the virus so that the Aβ

or immunogenic fragment thereof is displayed.

8. The pharmaceutical composition of claim 1, wherein the Aβ

or immunogenic fragment thereof is presented by a bacteria.

9. A method of treating a disease characterized by an amyloid deposit of Aβ

in a patient, comprising administering to a patient having the disease an effective dosage of Aβ

or an immunogenic fragment thereof presented by a virus or bacteria, wherein the Aβ

or the immunogenic fragment thereof induces an immune response comprising antibodies against Aβ and

thereby treating the disease.

10. The method of claim 9, wherein the disease is Alzheimer'"'"'s disease.

11. The method of claim 9, further comprising administering an adjuvant, wherein the adjuvant enhances the immune response to Aβ

.

12. The method of claim 9, wherein Aβ

is Aβ

43, Aβ

42, Aβ

41, Aβ

40, or Aβ

39.

13. The method of claim 9, wherein the immunogenic Aβ

fragment is Aβ

1-5.

14. The method of claim 9, wherein the immunogenic Aβ

fragment is Aβ

1-6.

15. The method of claim 9, wherein the Aβ

or immunogenic fragment thereof is presented by a virus.

16. The method of claim 15, wherein the Aβ

or immunogenic fragment thereof is expressed as a fusion protein with an outer surface protein of the virus so that the Aβ

or immunogenic fragment thereof is displayed.

17. The method of claim 15, wherein the Aβ

or immunogenic fragment thereof is chemically cross-linked with an outer surface protein of the virus so that the Aβ

or immunogenic fragment thereof is displayed.

18. The method of claim 9, wherein the Aβ

or immunogenic fragment thereof is presented by a bacteria.

19. A method of prophylaxis of a disease characterized by an amyloid deposit of Aβ

in a patient, comprising administering to a patient susceptible to the disease an effective dosage of Aβ

or an immunogenic fragment thereof presented by a virus or bacteria, wherein the Aβ

or the immunogenic fragment thereof induces an immune response comprising antibodies against Aβ and

thereby effecting prophylaxis of the disease.

20. The method of claim 19, wherein the disease is Alzheimer'"'"'s disease.

21. The method of claim 19, further comprising administering an adjuvant, wherein the adjuvant enhances the immune response to Aβ

.

22. The method of claim 19, wherein Aβ

is Aβ

43, Aβ

42, Aβ

41, Aβ

40, or Aβ

39.

23. The method of claim 19, wherein the immunogenic Aβ

fragment is Aβ

1-5.

24. The method of claim 19, wherein the immunogenic Aβ

fragment is Aβ

1-6.

25. The method of claim 19, wherein the Aβ

or immunogenic fragment thereof is presented by a virus.

26. The method of claim 25, wherein the Aβ

or immunogenic fragment thereof is expressed as a fusion protein with an outer surface protein of the virus so that the Aβ

or immunogenic fragment thereof is displayed.

27. The method of claim 25, wherein the Aβ

or immunogenic fragment thereof is chemically cross-linked with an outer surface protein of the virus so that the Aβ

or immunogenic fragment thereof is displayed.

28. The method of claim 19, wherein the Aβ

or immunogenic fragment thereof is presented by a bacteria.