Microprojection apparatus and system with low infection potential
First Claim
1. A transdermal agent delivery apparatus having a low infection potential comprising a microprojection member having a plurality of stratum corneum-piercing microprojections, at least one biologically active agent and at least one antimicrobial agent, wherein said biologically active agent and said antimicrobial agent are adapted to be delivered through microslits formed in a patient'"'"'s skin by said microprojections.
1 Assignment
0 Petitions
Accused Products
Abstract
A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.
52 Citations
34 Claims
- 1. A transdermal agent delivery apparatus having a low infection potential comprising a microprojection member having a plurality of stratum corneum-piercing microprojections, at least one biologically active agent and at least one antimicrobial agent, wherein said biologically active agent and said antimicrobial agent are adapted to be delivered through microslits formed in a patient'"'"'s skin by said microprojections.
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27. A method of transdermally delivering a biologically active agent to a patient, comprising the steps of:
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providing a delivery system including a microprojection member having a plurality of stratum corneum-piercing microprojections and a biocompatible coating disposed thereon having a biologically active agent and an antimicrobial agent; and
applying said coated microprojection member to a skin site of said patient via an actuator, whereby said plurality of stratum corneum-piercing microprojections pierce the stratum corneum and deliver said biologically active agent to said patient. - View Dependent Claims (28)
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29. A method of transdermally delivering a biologically active agent to a patient, comprising the steps of:
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providing a delivery system including a microprojection member having a plurality of stratum corneum-piercing microprojections and a gel pak having a hydrogel formulation of a biologically active agent and an antimicrobial agent;
applying said microprojection member to a skin site of said patient via an actuator, whereby said plurality of stratum corneum-piercing microprojections pierce the stratum corneum; and
placing said gel pak on said microprojection member, wherein said hydrogel formulation migrates into and through microslits in the stratum corneum produced by said microprojections. - View Dependent Claims (30)
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31. A method of transdermally delivering a biologically active agent to a patient, comprising the steps of:
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providing a delivery system including a microprojection member having a plurality of stratum corneum-piercing microprojections and a gel pak having a hydrogel formulation of a biologically active agent and an antimicrobial agent;
applying said microprojection member to a skin site of said patient via an actuator, whereby said plurality of stratum corneum-piercing microprojections pierce the stratum corneum;
removing said microprojection member; and
placing said gel pak on said treated skin site, wherein said hydrogel formulation migrates into and through microslits in the stratum corneum produced by said microprojections. - View Dependent Claims (32)
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33. A method of transdermally delivering a biologically active agent to a patient, comprising the steps of:
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providing a delivery system including a microprojection member having a plurality of stratum corneum-piercing microprojections, a solid film having a biologically active agent and an antimicrobial agent and a gel pak having a hydrogel formulation; and
applying said microprojection member to a skin site of said patient via an actuator, wherein said plurality of stratum corneum-piercing microprojections pierce the stratum corneum and wherein said hydrogel formulation hydrates and releases said biologically active agent from said solid film, allowing said biologically active agent to migrate into and through microslits in the stratum corneum produced by said microprojections. - View Dependent Claims (34)
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Specification