Transdermal delivery using emcapsulated agent activated by ultrasound and or heat
First Claim
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1. A method for delivery of substance through at least one dermal layer, the method comprising:
- providing a substance in microcapsules at a predetermined size, within a medium for holding the microcapsules;
placing the medium for holding the microcapsules on a surface of a patch adjacent the skin of a human or animal; and
applying energy to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules.
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Abstract
A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
110 Citations
62 Claims
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1. A method for delivery of substance through at least one dermal layer, the method comprising:
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providing a substance in microcapsules at a predetermined size, within a medium for holding the microcapsules;
placing the medium for holding the microcapsules on a surface of a patch adjacent the skin of a human or animal; and
applying energy to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A transdermal patch for infusing active substances into an animal body through the skin comprising:
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an inner disc, the inner disc including a encapsulated agents in microcapsules, wherein the microcapsules retain the encapsulated agents prior to activation by energy capable of rupturing the microcapsules;
an outer disc for attachment of the patch to the skin, thereby facilitating contact of the inner disc with a surface of the skin. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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- 32. A vehicle and active substance for delivery of the active substance by transdermally partitioning into the skin from an adhesive matrix of a transdermal patch, wherein the active substance is delivered transdermally dependent on a difference in chemical potentials of the active substance as contained in an external matrix or vehicle and the skin, wherein the active substance is contained within microcapsules which retain the active substance for delivery prior to activation by energy capable of rupturing the microcapsules.
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48. A transdermal device containing encapsulated agents in microspheres dispersed in a pressure-sensitive adhesive.
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49. A transdermal device containing encapsulated agents in microspheres dispersed in hydrogel.
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50. A transdermal device containing encapsulated agents in microspheres dispersed in hydrocolloid.
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51. A transdermal device comprising:
- encapsulated agent in microspheres dispersed in a medium; and
alcoholic, dialcoholic and/or glicerin medium in a reservoir type patch.
- encapsulated agent in microspheres dispersed in a medium; and
- 52. A method of delivering an agent encapsulated in microspheres or nanospheres in a patch matrix comprising the use of ultrasound at a resonant frequency between 0.1 and 100 MHz to rupture the micro or nanospheres, thereby releasing the agent into the patch matrix.
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54. A method of delivering an agent encapsulated in microspheres or nanospheres in a patch matrix comprising the use of heat to melt the spheres, to thereby release the agent.
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55. A device with multiple ultrasound sources for selectively rupturing microparticles in a selected area of a patch.
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56. A device with multiple heating sources for selectively melting microparticles in a selected area of a patch.
- 57. The method of the controlled transdermal delivery of an agent as a result of a controlled activation of the given parts of the transdermal patch using an ultrasound source or a heat source.
Specification