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Effervescent bisphosphonate formulation

  • US 20060034921A1
  • Filed: 10/19/2005
  • Published: 02/16/2006
  • Est. Priority Date: 01/05/2004
  • Status: Abandoned Application
First Claim
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1. An effervescent pharmaceutical formulation comprising as an active ingredient a bisphosphonate selected from the groups consisting of:

  • alendronate, cimadronate, clodronate, EB-1053, etidronate, ibandronate, neridronate, olpadronate, pamidronate, risedronate, tiludronate, YH 529, zoledronate, pharmaceutically acceptable salts and esters of the foregoing, and mixtures of the foregoing; and

    an acid source selected from the group consisting of;

    citric acid, tartaric acid, malic acid, fumaric acid, adipic acid, succinic acid;

    an anhydride of said acids;

    an acid salt selected from the group consisting of sodium dihydrogen phosphate, disodium dihydrogen pyrophosphate and sodium acid sulfite; and

    mixtures of the acids, anhydrides and acid salts;

    a carbonate source selected from the group consisting of;

    sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate, sodium sesquicarbonate, sodium glycine carbonate, and mixtures thereof;

    a binder selected from the group consisting of a non-reducing sugar, polyvinyl pyrrolidone, sodium chloride, sodium benzoate and sodium sulfate;

    a lubricant selected from the group consist of stearic acid salts, powdered sodium benzoate, L-leucine, sodium laurel sulfate and PEG; and

    optionally, one or more additional agents selected from the group consisting of flavoring agents, colorants, and sweeteners.

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