Capture arrays using polypeptide capture agents
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Abstract
A method of evaluating for the presence of a polypeptide in an analyte, using an addressable array of capture agents linked to a substrate. The analyte is exposed to the array and a set of fixed capture agents, such that the target molecules will bind to the array by means of the capture agents. After the target molecule has bound to the capture agents, it is modified using a label. The label does not interact or mark the capture agent. Kits using such arrays are further provided.
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Citations
43 Claims
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1-26. -26. (canceled)
- 27. An array of polypeptide capture agents, wherein said polypeptide capture agents are linked to a substrate and are free of a particular amino acid.
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34. An array of polypeptide capture agents, wherein said polypeptide capture agents are linked to a substrate and are made up of amino acids chosen from a group of amino acids that is free of arginine, lysine, cysteine, histidine, aspartic acid or glutamic acid.
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35. An array of polypeptide capture agents, wherein said polypeptide capture agents are linked to a substrate and made up of amino acids chosen from:
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ala, cys, asp, glu, phe, gly, his, ile, lys, leu, met, asp, pro, gln, ser, thr, val, trp, tyr;
ala, cys, asp, glu, phe, gly, his, ile, leu, met, asp, pro, gln, arg, ser, thr, val, trp, tyr;
ala, asp, glu, phe, gly, his, ile, lys, leu, met, asp, pro, gln, arg, ser, thr, val, trp, tyr;
ala, cys, asp, glu, phe, gly, ile, lys, leu, met, asp, pro, gln, arg, ser, thr, val, trp, tyr;
ala, cys, glu, phe, gly, his, ile, lys, leu, met, asp, pro, gln, arg, ser, thr, val, trp, tyr;
orala, cys, asp, phe, gly, his, ile, lys, leu, met, asp, pro, gln, arg, ser, thr, val, trp, tyr.
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Specification