Multi-functional biocompatible coatings for intravascular devices
First Claim
Patent Images
1. A polymeric coat, comprising:
- a first polymeric layer;
a second polymeric layer; and
a polymeric matrix layer interposed between the first and second polymeric layers, the polymeric matrix layer comprising at least one of a nitric oxide donor or a nitric oxide generator, wherein the polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood.
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Abstract
A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.
138 Citations
57 Claims
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1. A polymeric coat, comprising:
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a first polymeric layer;
a second polymeric layer; and
a polymeric matrix layer interposed between the first and second polymeric layers, the polymeric matrix layer comprising at least one of a nitric oxide donor or a nitric oxide generator, wherein the polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 54, 55, 56, 57)
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13. A polymeric coating, comprising:
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a first polymeric layer, a polymeric matrix layer disposed on the first polymeric layer, the polymeric matrix layer comprising at least one of a nitric oxide donor a nitric oxide generator, an aminated polymeric layer disposed on the polymeric matrix layer, and a bioactive agent. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. An intravascular device, comprising:
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a substrate; and
a coating applied to the surface of the substrate, the coating comprising;
a first polymeric layer;
a polymeric matrix layer disposed on the first polymeric layer, the polymeric matrix layer comprising at least one of a discrete nitric oxide adduct or a polymeric nitric oxide adduct, the at least one of the discrete nitric oxide adduct or the polymeric nitric oxide adduct capable of releasing NO;
a second polymeric layer disposed on the polymeric matrix layer, and a bioactive agent wherein the polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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33. A polymeric coating for an intravascular device, comprising:
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a polymeric layer, a polymeric matrix layer disposed on the polymeric layer, the polymeric matrix layer comprising at least one of a nitric oxide donor or a nitric oxide generator, and a bioactive agent dispersed within the polymeric matrix layer. - View Dependent Claims (34, 35, 36, 37, 38)
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39. A method for substantially eliminating thrombus formation, the method comprising:
inserting an intravascular device into a patient, wherein the intravascular device comprises;
a first polymeric layer;
a second polymeric layer;
a polymeric matrix layer interposed between the first and second polymeric layers, the polymeric matrix layer doped with at least one of a nitric oxide donor or a nitric oxide generator; and
a bioactive agent. - View Dependent Claims (40, 41, 42, 43)
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44. A method for forming a polymeric coating on an intravascular device, the method comprising:
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establishing a first polymeric layer on the device;
doping a polymeric matrix layer with at least one of a nitric oxide donor or a nitric oxide generator, the at least one of the nitric oxide donor or the nitric oxide generator capable of at least one of releasing and generating NO;
establishing the polymeric matrix layer on the first polymeric layer;
establishing a second polymeric layer on the polymeric matrix layer; and
establishing a bioactive agent via at least one of immobilization to a surface of the second polymeric layer and incorporation into the polyxneric matrix layer;
wherein the polymeric coating is adapted to substantially eliminate thombus formation when in contact with blood. - View Dependent Claims (45, 46)
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47. A polymeric coating, comprising:
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a first polymeric layer;
an active layer disposed on the first polymeric layer, the active layer doped with at least one of a discrete nitric oxide adduct or a polymeric nitric oxide adduct, the at least one of the discrete nitric oxide adduct or the polymeric nitric oxide adduct capable of releasing NO;
a second polymeric layer disposed on the active layer; and
a bioactive agent at least one of immobilized to a surface of the second polymeric layer, incorporated into the second polymeric layer, and incorporated into the active layer, wherein the polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. - View Dependent Claims (48, 49, 50, 51, 52)
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53. An intravascular device, comprising:
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a substrate; and
a coating applied to the surface of the substrate, the coating comprising;
a first polymeric layer;
a polymeric matrix layer disposed on the first polymeric layer, the polymeric matrix layer comprising a nitric oxide generator;
a second polymeric layer disposed on the polymeric matrix layer; and
a bioactive agent;
wherein the polymeric coating is adapted to substantially eliminates thrombus formation when in contact with blood.
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Specification