Ophthalmic drug delivery device
First Claim
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1. A drug delivery device for an eye, said eye comprising a sclera, a macula, and an extraocular muscle, comprising:
- a pharmaceutically active agent; and
a body having an extension for accomodating said extraocular muscle;
whereby when said device is disposed on an outer surface of said sclera so that said extension accomodates said extraocular muscle, said pharmaceutically active agent is disposed proximate said macula.
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Abstract
Ophthalmic drug delivery devices useful for delivery of pharmaceutically active agents to the posterior segment of the eye are disclosed. The devices may include extensions, immobilizing structures, and/or geometries to help properly locate, and prevent migration of, the devices.
129 Citations
30 Claims
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1. A drug delivery device for an eye, said eye comprising a sclera, a macula, and an extraocular muscle, comprising:
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a pharmaceutically active agent; and
a body having an extension for accomodating said extraocular muscle;
whereby when said device is disposed on an outer surface of said sclera so that said extension accomodates said extraocular muscle, said pharmaceutically active agent is disposed proximate said macula. - View Dependent Claims (2, 3, 4, 5)
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6. A drug delivery device for an eye, said eye comprising a sclera and an extraocular muscle, comprising:
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a pharmaceutically active agent; and
a body having an extension for accomodating said extraocular muscle;
whereby when said device is disposed on an outer surface of said sclera so that said extension accomodates said extraocular muscle, said extension helps to immobilize and to prevent migration of said device. - View Dependent Claims (7, 8, 9)
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10. A drug delivery device for an eye, said eye comprising an extraocular muscle, comprising:
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a pharmaceutically active agent; and
a body having an extension for accomodating said extraocular muscle, said extension being capable of extending from said body in a first position so as to accommodate said extraocular muscle, and said extension being capable of folding above or beneath said body in a second position so as to facilitate implantation of said device.
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11. A drug delivery device for an eye, said eye comprising a sclera, comprising:
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a pharmaceutically active agent; and
a body having a scleral surface for contacting said sclera and an immobilizing structure disposed on said scleral surface. - View Dependent Claims (12, 13, 14)
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15. A drug delivery device for an eye, said eye comprising a sclera, a macula, a superior rectus muscle, and a lateral rectus muscle, comprising:
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a body having;
a scleral surface;
a well having an opening to said scleral surface; and
a geometry that facilitates an implantation of said device on an outer surface of said sclera, between said superior rectus muscle and said lateral rectus muscle, beneath said lateral rectus muscle, and with said well disposed proximate said macula; and
an inner core disposed in said well and comprising a pharmaceutically active agent. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. A method of delivering a pharmaceutically active agent to an eye, said eye comprising a sclera, a macula, a superior rectus muscle, and a lateral rectus muscle, comprising the steps of:
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providing a drug delivery device comprising;
a pharmaceutically active agent; and
a body having a geometry that facilitates an implantation of said device on an outer surface of said sclera, between said superior rectus muscle and said lateral rectus muscle, beneath said lateral rectus muscle, and with said pharmaceutically active agent disposed proximate said macula; and
disposing said device on an outer surface of said sclera, between said superior rectus muscle and said lateral rectus muscle, beneath said lateral rectus muscle, and with said pharmaceutically active agent disposed proximate said macula. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30)
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Specification