Oral drug delivery system

• US 20060039977A1
• Filed: 02/04/2002
• Published: 02/23/2006
• Est. Priority Date: 02/02/2001
• Status: Abandoned Application

• Current Assignee: United Pharmaceuticals Manufacturing Co., Limited (Munir Sukhtian Pharmaceuticals)
• Original Assignee: United Pharmaceuticals Manufacturing Co., Limited (Munir Sukhtian Pharmaceuticals)
• Inventors: Tucker, Mark Rupert, Watts, Jonathan, Stokes, Alistair, Flahive, Eamon
• Application Number:
  US10/470,711
• Publication Number:
  US 20060039977A1
• Time in Patent Office: Days
• US Class Current: 424/473
• CPC Class Codes: A61K 9/009 Sachets, pouches characterised by the material or function of the envelope with gastric retention A61K9/0065; sachets which are not administered but function merely as a container are classified according to the content, e.g. sachets comprising powder for reconstitution of a drink A61K9/0095

Abstract

There is disclosed an oral delivery system, which comprises: a sachet at least partially formed from at least one microporous permeable membrane, and defining a cavity; a physiologically active substance dissolved or dispersed in a liquid or gel, within the cavity, the microporous or permeable membrane being in contact with the liquid or gel and being permeable to the physiologically active substance in the liquid or gel; and an encapsulating layer surrounding the sachet; characterised in that either: a) the membrane is hydrophilic and the contents of the sachet are hydrophobic; or b) the membrane is hydrophobic and the contents of the sachet are hydrophilic; whereby, in use, the encapsulating layer is first dissolved in the gastro-intestinal tract (GIT) and thereafter passage of the physiologically active substance into the GIT through the membrane is rate-controlled. A method of manufacturing the oral delivery system is also disclosed.

Claims

1. An oral delivery system, which comprises:

a sachet at least partially formed from at least one microporous or permeable membrane, and defining a cavity;

a physiologically active substance dissolved or dispersed in a liquid or gel, within the cavity, the microporous or permeable membrane being in contact with the liquid or gel and being permeable to the physiologically active substance in the liquid or gel; and

an encapsulating layer surrounding the sachet;

characterized in that either;

a) the membrane is hydrophilic and the contents or the sachet are hydrophobic;

or

b) the membrane is hydrophobic and the contents of the sachet are hydrophilic;

whereby, in use, the encapsulating layer is first dissolved in the gastro-intestinal tract (GIT) na d thereafter passage of the physiologically active substance into the GIT through the membrane is rate-controlled.

2. An oral delivery system according to claim 1, wherein the membrane is selected from polyethylene, polyvinyl acetate, copolymers of ethyl vinylacetate, polymethacrylate, polyvinyl chloride, ethylcelluloses, polyamides, polyurethanes, polyethers, and copolyesters.

3. An oral delivery system according to claim 1, or 2, wherein the encapsulating layer is gelatin.

4. An oral delivery system according to claim 1, wherein the sachet is enterically coated to provide a further sustained release function.

5. A method of manufacturing an oral delivery system according to claim 1, wherein two membranes are brought together at their edge regions, with a cavity being left between the edge regions, into which cavity is introduced the physiologically active substance dissolved or dispersed in the liquid or gel, the cavity sealed, and then encapsulated within a suitable encapsulating material.

6. A method according to claim 5, wherein the cavity is sealed transversely at intervals and cut in the region of the seals, so as to form individual sachets.

7-8. -8. (canceled)