Apparatus and method for transdermal delivery of vascular endothelial growth factors
First Claim
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1. A device for transdermally delivering a VEGF-based agent to a patient, comprising:
- a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating being formed from a coating formulation having at least one VEGF-based agent disposed thereon.
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Abstract
An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or assembly) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the VEGF-based agent is contained in a biocompatible coating that is applied to the microprojection member.
25 Citations
56 Claims
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1. A device for transdermally delivering a VEGF-based agent to a patient, comprising:
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a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a biocompatible coating disposed on said microprojection member, said coating being formed from a coating formulation having at least one VEGF-based agent disposed thereon. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A delivery system for transdermally delivering a VEGF-based agent to a patient, comprising:
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a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient; and
a hydrogel formulation having at least one VEGF-based agent, said hydrogel formulation being in communication with said microprojection member. - View Dependent Claims (24, 25, 26, 27)
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28. A delivery system for transdermally delivering a VEGF-based agent to a patient, comprising:
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a microprojection member having a plurality of microprojections that are adapted to pierce the stratum corneum of the patient;
a solid state formulation disposed proximate said microprojection member; and
a hydrogel formulation, said hydrogel formulation being in communication with said solid state formulation. - View Dependent Claims (29, 30, 31)
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32. A method of transdermally delivering a VEGF-based agent to a patient, comprising the steps of:
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providing a microprojection member having a plurality of microprojections, said microprojection member having a coating disposed thereon, said coating including at least one VEGF-based agent;
applying said microprojection member to a skin site of said patient, whereby said plurality of microprojections pierce the stratum corneum and deliver said VEGF-based agent to said patient; and
removing said microprojection member from said skin site. - View Dependent Claims (33, 34)
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35. A method for transdermally delivering a VEGF-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member and a gel pack, said microprojection member including a plurality of microprojections, said gel pack including a hydrogel formulation having at least one VEGF-based agent;
applying said microprojection member-gel pack assembly to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum, and whereby said hydrogel formulation is released from said gel pack and migrates into and through said microslits formed by said microprojections; and
removing said microprojection member-gel pack assembly from said skin site. - View Dependent Claims (36, 37, 38, 39, 40)
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41. A method for transdermally delivering a VEGF-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member and a gel pack, said microprojection member including a plurality of microprojections, said gel pack including a hydrogel formulation having at least one VEGF-based agent;
applying said microprojection member to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum;
placing said gel pack on said microprojection member, whereby said hydrogel formulation is released from said gel pack and migrates into and through said microslits formed by said microprojections; and
removing said microprojection member from said skin site. - View Dependent Claims (42, 43, 44, 45, 46)
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47. A method for transdermally delivering a VEGF-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member and a gel pack, said microprojection member including a plurality of microprojections, said gel pack including a hydrogel formulation having at least one VEGF-based agent;
applying said microprojection member to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum;
removing said microprojection member from said skin site;
placing said gel pack on said pre-treated skin site, whereby said hydrogel formulation is released from said gel pack and migrates into and through said microslits formed by said microprojections; and
removing said gel pack from said skin site. - View Dependent Claims (48, 49)
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50. A method for transdermally delivering a VEGF-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member, a gel pack and a solid state formulation, said microprojection member including a plurality of microprojections, said gel pack including a hydrogel formulation, said solid state formulation being disposed proximate said microprojection member and including at least one VEGF-based agent;
applying said microprojection assembly to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum, and whereby said hydrogel formulation is released from said gel pack and releases said agent contained in said solid state formulation and said agent and hydrogel formulation migrates into through said microslits formed by said microprojections; and
removing said microprojection assembly from said skin site. - View Dependent Claims (51, 52)
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53. A method for transdermally delivering a VEGF-based agent to a patient, comprising the steps of:
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providing a microprojection assembly having a microprojection member and a gel pack, said microprojection member including a plurality of microprojections, said solid state formulation being disposed proximate said microprojection member and including at least one VEGF-based agent;
providing a gel pack having a hydrogel formulation;
applying said microprojection assembly to a skin site of said patient, whereby a plurality of microslits are formed in the patient'"'"'s stratum-corneum;
placing said gel pack on said microprojection assembly, whereby said hydrogel formulation is released from said gel pack and releases said agent contained in said solid state formulation and said agent and hydrogel formulation migrates into through said microslits formed by said microprojections; and
removing said microprojection assembly from said skin site. - View Dependent Claims (54, 55, 56)
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Specification