Calcium channel inhibitor
First Claim
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1. A calcium channel inhibitor, wherein dipeptide Val-Tyr or a substance containing dipeptide Val-Tyr is an effective ingredient.
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Abstract
The present invention relates to an agent which inhibits or suppresses calcium channel where dipeptide Val-Tyr (VY) or a substance containing the same is an effective ingredient. Examples of the substance containing VY are hydrolysate (sardine peptide) of fish meat of sardine, etc., and VY or VY-containing substance is also able to be used as food/beverage in addition to pharmaceuticals. In accordance with the present invention, it has been clarified that, in reduction of blood pressure, VY has two actions of calcium channel inhibition in addition to ACE inhibition.
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Citations
18 Claims
- 1. A calcium channel inhibitor, wherein dipeptide Val-Tyr or a substance containing dipeptide Val-Tyr is an effective ingredient.
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4. A calcium channel inhibitor, wherein an effective ingredient is a peptide α
- -1000 containing dipeptide Val-Tyr which is prepared in such a manner that fish meat is thermally denatured and hydrolyzed by treating with neutral or alkaline protease, the enzyme is inactivated and a separating treatment is conducted.
- View Dependent Claims (6, 8, 10)
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5. A calcium channel inhibitor, wherein a peptide α
- -1000 having the following physico-chemical properties is an effective ingredient;
(A) Molecular weight;
200 to 10,000 (as measured by Sephadex G-25 column chromatography);
(B) Melting point;
Colored at 119°
C. (decomposition point);
(C) Specific rotatory power;
[α
]D20=−
22°
;
(D) Solubility in solvents;
It is easily soluble in water but rarely soluble in ethanol, acetone and hexane;
(E) Chemical differentiation in acidic, neutral or basic character;
Neutral;
(F) Appearance and constituent components;
It is white powder comprising 5.14 w/w % of water (by a vacuum heating and drying method), 87.5 w/w % of protein (by a Kjeldahl method with a nitrogen/protein conversion coefficient of 6.25), 0 w/w % of lipid (by a Soxhlet extraction method) and 5.0 w/w % of ash (by a direct ashing method);
(G) Characteristics;
It is a peptide mixture derived from fish meat and obtained by inactivating an autolytic enzyme by heating followed by hydrolyzing with protease;
it contains dipeptide Val-Tyr and has an action of inhibition or suppression of calcium channel;
(H) Infrared absorption spectrum;
FIG. 1 ; and
(I) Ultraviolet absorption spectrum;
FIG. 2 . - View Dependent Claims (13)
- -1000 having the following physico-chemical properties is an effective ingredient;
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7. A calcium channel inhibitor, wherein a peptide Y-2 having the following physico-chemical properties is an effective ingredient:
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(A) Molecular weight;
200 to 10,000 (as measured by high-performance liquid chromatography using ASAHIPAK GS-320);
(B) Melting point;
It is colored and decomposed at 138°
C.;
(C) Specific rotatory power;
[α
]D20=−
40°
;
(D) Solubility in solvents;
It is easily soluble in water but rarely soluble in ethanol, acetone and hexane;
(E) Chemical differentiation in acidic, neutral or basic character;
Neutral;
pH of from 5.0 to 8.0 (10 w/v % solution);
(F) Appearance of the substance;
It is white to light yellow powder;
(G) Constituent components;
It comprises 2.72 w/w % of water (by a heating and drying method under ordinary pressure), 87.25 w/w % of protein (by a Kjeldahl method with a nitrogen/protein conversion coefficient of 6.25), 0 w/w % of lipid (by a Soxhlet extraction method) and 0.20 w/w % of ash (by a direct ashing method);
(H) Physiological properties;
It contains a dipeptide Val-Tyr and has an inhibitive or suppressing action to calcium channel;
(I) Infrared absorption spectrum;
FIG. 4 ; and
(J) Ultraviolet absorption spectrum;
FIG. 5 . - View Dependent Claims (14)
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9. A calcium channel inhibitor, wherein a peptide SY having the following physico-chemical properties is an effective ingredient:
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(A) Molecular weight;
200 to 10,000 (as measured by high-performance liquid chromatography using ASAHIPAK GS-320);
(B) Melting point;
It is colored and decomposed at 138 ±
3°
C.;
(C) Solubility in solvents;
It is easily soluble in water but rarely soluble in ethanol, acetone and hexane;
(D) Appearance and property;
It is white to light yellow powder;
(E) Liquid property (pH);
4.0 to 6.0;
(F) Constituent components;
It comprises 1 to 5 w/w % of water (by a heating and drying method under ordinary pressure), 84 to 94 w/w % of protein (by a micro-Kjeldahl method), 0.5 w/w % of lipid (by a Soxhlet extraction method), 4±
2 w/w % of ash (by a direct ashing method) and 1 to 3 w/w % of Na (by an atomic absorption spectrophotometry);
(G) Physiological properties;
It contains a dipeptide Val-Tyr and has an inhibitive or suppressive action to calcium channel;
(H) Infrared absorption spectrum;
FIG. 7 ; and
(I) Ultraviolet absorption spectrum;
FIG. 8 . - View Dependent Claims (15)
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11. A calcium channel inhibitor, wherein a peptide SY-MD having the following physico-chemical properties is an effective ingredient:
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(A) Molecular weight;
200 to 10,000;
(B) Melting point;
It is colored and decomposed at 138 ±
3°
C.;
(C) Solubility in solvents;
It is easily soluble in water but rarely soluble in ethanol, acetone and hexane;
(D) Appearance and property;
It is white to light yellow powder;
(E) Liquid property (pH);
4.0 to 6.0;
(F) Constituent components;
It comprises 2 to 6 w/w % of water (by a heating and drying method under ordinary pressure), 90 to 98 w/w % of protein (by a micro-Kjeldahl method), 0.5 w/w % of lipid (by a Soxhlet extraction method), 3.0 w/w % of ash (by a direct ashing method) and 0.1 to 0.2 w/w % of Na (by an atomic absorption spectrophotometry);
(G) Physiological properties;
It contains a dipeptide Val-Tyr and has an inhibitive or suppressive action to calcium channel;
(H) Infrared absorption spectrum;
FIG. 9 ; and
(I) Ultraviolet absorption spectrum;
FIG. 10 . - View Dependent Claims (16)
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12. Food for inhibition or suppression of calcium channel, wherein a substance which is derived from natural substance and contains dipeptide Val-Tyr is an effective ingredient.
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17. A method for inhibiting calcium channel in a human in need thereof, which comprises administering a material comprising dipeptide Val-Tyr to the human in an effective amount.
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18. A method for inhibiting calcium channel in a human in need thereof, which comprises ingesting a food comprising dipeptide Val-Tyr in an effective amount.
Specification