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Methods of use related to xerostomia

  • US 20060040903A1
  • Filed: 10/25/2005
  • Published: 02/23/2006
  • Est. Priority Date: 12/09/1997
  • Status: Abandoned Application
First Claim
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1. A method for treating xerostomia associated with radiation therapy for head and neck cancer in a human, which comprises administering to said human a therapeutically effective amount of a dosage form comprising a thermally stable, sterile, crystalline compound of the formula:


  • R1NH(CH2)nNH(CH2)mSR2 or a pharmaceutically acceptable addition salt or hydrate thereof, wherein R1 is hydrogen, C5-C7 aryl, C2-C7 acyl, or C1-C7 alkyl;

    R2 is hydrogen, PO3H2 or R3 wherein R3 is R1NH(CH2)nNH(CH2)mS—

    ;

    n is an integer from 1 to 10; and

    m is an integer from 1 to 10.

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