Triptolide analogs for the treatment of autoimmune and inflammatory disorders

• US 20060040907A1
• Filed: 08/17/2004
• Published: 02/23/2006
• Est. Priority Date: 10/02/2000
• Status: Active Grant

• Current Assignee: Dennis C. Liotta, Hariharan Venkatesan, James P. Snyder
• Original Assignee: Dennis C. Liotta, Hariharan Venkatesan, James P. Snyder
• Inventors: Venkatesan, Hariharan, Snyder, James P., Liotta, Dennis C.
• Granted Patent: US 7,557,139 B2
• Time in Patent Office: Days
• US Class Current: 514/183
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/06 Antigout agents, e.g. antihyperuricemic or uricosuric agents
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 29/02 without antiinflammatory effect
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07C 2601/14 : The ring being saturated
• CPC Class Codes: C07C 37/002 : by transformation of a functional group, e.g. oxo, carboxyl
• CPC Class Codes: C07C 39/11 : Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
• CPC Class Codes: C07C 39/17 : containing other rings in addition to the six-membered aromatic rings , e.g. cyclohexylphenol
• CPC Class Codes: C07C 45/46 : Friedel-Crafts reactions
• CPC Class Codes: C07C 47/565 : all hydroxy groups bound to the ring
• CPC Class Codes: C07D 303/04 : containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
• CPC Class Codes: C07D 303/14 : by free hydroxyl radicals
• CPC Class Codes: C07D 303/32 : by aldehydo- or ketonic radicals
• CPC Class Codes: C07D 493/10 : Spiro-condensed systems

Abstract

The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.

Claims

1. A compound of the formula (I):

21. A method for the treatment or prophylaxis of an inflammatory disorder in a host comprising administering an effective treatment amount of a compound according to any one of claim 1-20.

22. A method for the treatment or prophylaxis of an autoimmune disorder in a host comprising administering an effective treatment amount of a compound according to any one of claim 1-20.

2. A compound of the formula (II)

3. A compound of the formula (III):

4. A compound of the formula (IV):

5. A compound of the formula (V):

6. A compound of the formula (VI):

7. A compound of the formula (VII):

8. A compound of the formula (VIII):

9. A compound of the formula (IX):

10. A compound of the formula (X):

11. A compound of the formula (XI):

12. A compound of the formula (XII):

13. A compound of the formula (XIII):

14. A compound of the formula (XIV):

15. A compound of the formula (XV):

16. A compound of the formula (XVI):

17. A compound of the formula (XVII):

18. A compound of the formula (XVIII):

19. A compound of the formula (XIX):

20. A compound of the formula (XX):