Cosmetic compositions

• US 20060045892A1
• Filed: 08/25/2004
• Published: 03/02/2006
• Est. Priority Date: 08/25/2004
• Status: Active Grant

• Current Assignee: Molecular Research Center Incorporated
• Original Assignee: Molecular Research Center Incorporated
• Inventors: Chomczynski, Piotr
• Granted Patent: US 7,812,057 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth

Abstract

A composition and method for improving skin appearance by reducing skin redness and symptoms associated with skin inflammation, irritation and skin aging by topically treating skin is disclosed. In this composition and method, an active material having the formula given below is applied to the patient at the site of said condition:
wherein R¹ is selected from —OH and C₁-C₃ alkyl OH; and R², R³, R⁴, R⁵ and R⁶ are independently selected from —H, —OH, C₁-C₆ alkyl, and C₃-C₆ cycloalkyl. The active material should contain no more than five —OH groups. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures of those materials. A method of maintaining healthy hair and reducing hair loss using these actives is also disclosed.

Claims

1. A method of maintaining healthy skin and skin appearance by reducing redness and symptoms associated with skin ailments in humans comprising topically applying to a person in need of such treatment a safe and effective amount of the compound having the following formula, at the site of said condition:

2. The method according to claim 1 wherein the compound is applied to the skin in an amount of from 0.001 to about 10 mg/cm².

3. The method according to claim 2 wherein the compound is applied to the skin in a topical cosmetic carrier.

4. The method according to claim 3 wherein the compound is selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl-1-propanol, 1,4-cyclohexanediol, 1,3 cyclohexanediol, 1,2-cyclohexanediol, 4-cyclohexylcyclohexanol, 4-methylcyclohexanol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, 1,4,5-cyclohexanetriol, and mixtures thereof.

5. The method according to claim 3 wherein the compound contains no more than 3 hydroxyl groups.

6. The method according to claim 5 wherein the compound is selected from 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures thereof.

7. The method according to claim 3 wherein R², R³, R⁴, R⁵ and R⁶ are independently selected from —

H and —

OH.

8. The method according to claim 3 wherein the cosmetic carrier comprises a material selected from propylene glycol, glycerin, water, dimethylisosorbide, and mixtures thereof.

9. The method according to claim 6 wherein the cosmetic carrier comprises a material selected from propylene glycol, glycerin, water, dimethylisosorbide, and mixtures thereof.

10. The method according to claim 3 wherein the carrier is formulated in a composition selected from solutions, suspensions, gels, pastes, solids and soaps.

11. The method of claim 3 where the topical application of the compound is supplemented by a medically active oral supplement.

12. The method of claim 11 where the oral supplement is a tomato product selected from juice, homogenate, condensate, paste, extracts, extracted products, and mixtures thereof.

13. A method of maintaining healthy hair and reducing hair loss in humans comprising topically applying to the scalp of a patient in need of such treatment a safe and effective amount of a compound having the following formula:

14. The method according to claim 13 wherein the compound is selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl-1-propanol, 1,4-cyclohexanediol, 1,3 cyclohexanediol, 1,2-cyclohexanediol, 4-cyclohexylcyclohexanol, 4-methylcyclohexanol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, 1,4,5-cyclohexanetriol, and mixtures thereof.

15. The method according to claim 14 wherein the compound is selected from 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures thereof.

16. The method according to claim 13 wherein the compound is applied to the scalp in a topical cosmetic carrier.

17. The method according to claim 13 wherein the compound is formulated in a composition selected from solutions, lotions, shampoos, hair conditioners, hair sprays or hair mousses.

18. A cosmetic composition comprising:

(a) from about 0.001% to about 10% of a compound having the formula;

wherein R¹ is selected from —

OH, and C₁-C₃ alkyl OH; and

R², R³, R⁴, R⁵ and R⁶ are each independently selected from —

H, —

OH, C₁-C₆ alkyl and C₃-C₆ cycloalkyl;

provided that the compounds includes no more than five —

OH groups.

(b) the balance being a topical cosmetic carrier.

19. The composition according to claim 18 wherein the compound is selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl- 1-propanol, 1,4-cyclohexanediol, 1,3 cyclohexanediol, 1,2-cyclohexanediol, 4-cyclohexylcyclohexanol, 4-methylcyclohexanol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, 1,4,5-cyclohexanetriol, and mixtures thereof

20. The composition according to claim 18 wherein the compound is selected from 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures thereof.

21. The composition according to claim 19 wherein the cosmetic carrier comprises a material selected from propylene glycol, glycerin, water, dimethylisosorbide, and mixtures thereof.

22. The composition according to claim 21 wherein the cosmetic carrier comprises glycerin.

23. The composition according to claim 22 wherein the compound is selected from 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2,3-cyclohexanetriol, 1,3,5-cyclohexanetriol, and mixtures thereof.

24. The composition according to claim 18 wherein the compound contains no more than 3 hydroxyl groups.

25. The composition according to claim 18 wherein R², R³, R⁴, R⁵ and R⁶ are independently selected from —

H and —

OH.

26. The composition according to claim 18 which contains a safe and effective amount of a supplemental cosmetic or pharmaceutical active compound.