Method and apparatus for detecting analyte with filter
First Claim
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1. A method of detecting an analyte, comprising:
- flowing a fluid through a filter, said fluid carrying signal producing members smaller in size than said analyte and having affinity to specifically attach to said analyte, said filter adapted for trapping said analyte while allowing passage of unattached ones of said signal producing members; and
sensing a signal produced by one or more of said signal producing members upstream of said filter so as to detect said analyte trapped by said filter.
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Abstract
To detect an analyte, a fluid is flown through a filter. The fluid carries signal producing members smaller in size than the analyte and having affinity to specifically attach to the analyte. The filter is adapted for trapping the analyte while allowing passage of unattached ones of the signal producing members. A signal produced by one or more of the signal producing members can be sensed upstream of the filter to detect the analyte trapped by the filter.
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Citations
32 Claims
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1. A method of detecting an analyte, comprising:
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flowing a fluid through a filter, said fluid carrying signal producing members smaller in size than said analyte and having affinity to specifically attach to said analyte, said filter adapted for trapping said analyte while allowing passage of unattached ones of said signal producing members; and
sensing a signal produced by one or more of said signal producing members upstream of said filter so as to detect said analyte trapped by said filter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A device for detecting an analyte, comprising:
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a body having walls defining a fluid path;
a filter for trapping said analyte in said fluid path but allowing passage of signal producing members smaller in size than said analyte and having affinity to specifically attach to said analyte;
said analyte trapped in said path by said filter; and
at least one of said walls allowing transmission of a signal produced by said signal producing members attached to said analyte such that said analyte can be detected by sensing said signal. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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27. A device for detecting an analyte, comprising:
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a wall having a first portion and a second portion, said first and second portions defining a fluid path, said path having a substantially closed, downstream end and an open, upstream end, said path narrowing from said upstream end towards said downstream end, each of said first and second portions having a plurality of openings disposed along said path to allow a fluid to pass through said wall, said openings being sufficiently small for preventing passage of an analyte carried by said fluid, wherein said fluid tends to force said analyte in said path towards said downstream end to leave at least some of said openings unblocked by said analyte;
an inlet in fluid communication with said path for feeding said fluid and said analyte into said upstream end of said path; and
an outlet in fluid communication with said openings for allowing said fluid to exit said path. - View Dependent Claims (28, 29, 30)
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31. A device for detecting an analyte, comprising:
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a body having walls defining a fluid path;
a filter for trapping said analyte in said fluid path but allowing passage of signal producing members smaller in size than said analyte and having affinity to specifically attach to said analyte;
a screen disposed upstream of said filter in said fluid path for blocking objects larger than said analyte; and
at least one of said walls allowing transmission of a signal produced by said signal producing members attached to said analyte such that said analyte can be detected by sensing said signal. - View Dependent Claims (32)
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Specification